New techniques help increase the effectiveness of artificial insemination

Last June, a healthy baby boy was born with artificial insemination (IVF) using new generation gene screening techniques, selecting the most viable embryo to perform IVF.

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This new method (NGS) uses DNA sequencing to detect chromosomal abnormalities and defective genes before the embryo is implanted in the uterus.

According to the study's author, Dagan Wells of NIHR Biomedical Research Center of Oxford University, during the process of treating infertility, many embryos were created but very few of these could develop into fetus due to genetic abnormalities.

The NGS method allows an increased ability to detect these abnormalities and helps determine which embryos have the highest chance of developing a fetus to implant into the uterus.

Stuart Lavery is in charge of the IVF department of Hammersmith Hospital in London, a new technique that is more effective in gene diagnosis before embryo transplantation, but a randomized trial program is needed to confirm its accuracy. this method.

Previously, Wells tested this method to produce high results for "abnormal" embryos in the laboratory, then use this method to help the two couples who are using the IVF method. Two wives aged 35-39 and one had ever had a miscarriage.

This method has identified three healthy embryos (pre-embryos), then each wife has an embryo implanted and has a healthy pregnancy.

The first pregnancy gave birth to a healthy baby boy in June in Pennsylvania. The second case is about to give birth.

According to Wells, the new method is only as low as 50-70% of the cost of the current chromosome screening method. Currently embryo screening in IVF is used for older women at high risk of chromosomal abnormalities and those who have miscarriage.

Only about 30% of IVF use cases are successful and the cause of the condition has not been determined, but it is suspected that the gene is defective.

According to the European Association of Breeding and Embryology (ESHRE), 1 in 6 couples in the world experience reproductive difficulties at least once in their lives.