Detecting molecule Bim cut blood supply nourishing cancer cells

Scientists have discovered a mechanism that cuts off blood vessels that nourish hard tumors, such as cancers found in breast, bowel, and lung cancer patients.

A special molecule is produced in cells inside the blood vessels, called Bim , that are programmed to create the death of cells, which are considered bad or no longer needed in our bodies.

But solid cancers produce a hormone-like protein that deliberately blocks Bim production in cells in blood vessels that nourish the cancer, thus preventing Bim from cutting the vessels. Blood nourishes the cancerous mass.

Cutting the blood supply to cancer can help kill them

" We have discovered the mechanism of cells that make up blood vessels that nourish the growth of cancer that is destroyed by some chemotherapy drugs currently in use ," said Dr. Andreas Strasser, member. of the research team working in the Department of Hematology and Cancer, Molecular Genetics Research Institute of Walter and Eliza Hall, in Melbourne, Australia.

The results of the study contribute to providing the information needed to produce chemotherapy drugs that work in combination with the attack of cancer and the removal of blood vessels that nourish the cancer. More specifically, the first drug can directly fight cancer, while a second drug can mimic Bim's mechanism of action or encourage more Bim production in nourishing blood vessels. cancer block.

" With this new drug, cancer patients will save a lot of money and time. Because they get twice the treatment effect ," Dr. Strasser said.

The results of the study were published online in the Journal of Experimental Medicine.

This study is funded by the Victoria Cancer Society, the National Society for Medical and Medical Research, Australian Research Society, the US National Institutes of Health, Leukemia and lymphoma and the pharmaceutical company. Genentech, USA.

" We are delighted with this finding, but at the same time to lead to better treatments, to produce new drugs, requiring a huge amount of chemical testing and evaluation, as well as legal barriers, "said Dr. Strasser. " Need to be careful to go to the destination ".

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