Anti-cancer substance discovered in a familiar mushroom

US researchers have found prostate cancer-fighting properties in one of the world's most widely grown and eaten mushrooms.

In a study recently published in the medical journal Clinical and Translational Medicine , a team of authors from the American cancer research organization City of Hope demonstrated the anti-cancer ability of Agaricus bisporus mushroom extract.

Agaricus bisporus, also known by familiar names such as button mushroom or white button mushroom , is one of the most widely used mushrooms as food.

Agaricus bisporus mushroom extract has the ability to support the fight against prostate cancer - (AI Illustration: Anh Thu).

According to Science Alert , like many other tumors, prostate cancer tumors protect themselves by producing myeloid-derived suppressor cells (MDSCs), which prevent the patient's own immune system from destroying the pathogen.

New research shows that mushroom extract has the power to break down this shield.

In a previous phase I clinical trial, researchers at City of Hope found promising signs that white button mushroom extract may help control prostate cancer.

Some volunteers also had reduced circulating MDSC levels.

After several months of taking a twice-daily supplement of mushroom extract, some men have reduced prostate cancer markers in their blood to undetectable levels.

Recently, researchers conducted a parallel mouse experiment and phase II clinical trial to investigate the mechanism behind the observed effects.

In mice with prostate cancer, mushroom extract significantly slowed tumor growth and prolonged survival.

In an ongoing phase II clinical trial, patients receiving the mushroom extract had lower levels of MDSCs and higher numbers of anti-tumor immune cells.

However, this does not mean that mushrooms can be used as a substitute for medicine.

Instead, it can be used as a safe nutritional supplement to support other treatments, by boosting the immune system and suppressing disease.

In addition, research steps also show that eating this type of mushroom also helps prevent prostate cancer in people who do not have the disease.

Essentially, mushrooms, like other mushrooms, are rich in soluble fiber, protein, lipids, and phytochemicals, all of which can be toxic to cancer cells.

The authors said research is ongoing to develop appropriate nutritional therapy as a supportive intervention for cancer patients.

Even so, it's certainly good for you to occasionally add fresh mushrooms to your diet from now on.