Discovered super-antibodies that can neutralize HIV

The work was carried out by the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT), Harvard University, Darmouth College in New Hampshire - USA, and published in the medical journal Science Traslational Medicine.

US scientists have investigated the role of VR07, a member of the IgG antibody family that has the potential to pave the way for monoclonal antibody therapy against the HIV virus.

HIV virus

According to Dr. Jacqueline M. Brady, lead author, broad-spectrum neutralizing antibodies are inherently able to block viral entry and promote innate immune responses against HIV-infected cells.

However, as we all know, the antibodies that humans possess are not strong enough to fight the HIV virus. But one way to strengthen this natural immune system could be the way out.

According to Medica Xpress, the scientists studied VR07, a member of the IgG subclass and a type of broadly neutralizing antibody.

In experiments on cloned mice, VR07 as an immunoprophylaxis has demonstrated the ability to help prevent HIV from being transmitted vaginally - the probability of infection depends on increasing or decreasing the effectiveness of the molecules. VR07 class. From there, they determined that VR08 with the IgG1 subclass could block transmission even at low concentrations.

This discovery provides an important resource in the field of monoclonal antibody research - a "warrior" that stops viruses. In this context it is HIV, an incurable virus.

The authors say they are still looking for the most effective way to isolate the newly discovered HIV superantibodies, the first step in finding a widely used cure.