New drugs treat HIV and malaria

Century disease HIV / AIDS and malaria share a number of similarities in terms of molecules. Therefore, it is possible that the "super drug" may soon appear to cure both diseases.

It is a drug that inhibits resolution , the drug that scientists create to destroy HIV by blocking the process of making proteins from this virus. 'Resonant inhibitors are in the process of clinical trials and are currently the most promising HIV drugs' , Photini Sinnis, director of the Parasitology Laboratory of NYU Langone Medical Center (USA), said. know.

' These substances have completely changed the way of treating HIV in recent years. People who take this medicine will not lose their lives because of AIDS. '

Decomposing inhibitors are enzymes that can cut proteins into shapes so they work positively. HIV-mediated inhibitors block HIV virus in their path by blocking one of its proteolytic enzymes from functioning. When there is no proteolytic protein, HIV proteins are not broken down and activated, making the HIV particles unable to assemble to form new elements. The body's natural mechanism is to kill HIV particles to prevent replicating viruses to keep the body's number of manageable HIV cells.

This new drug can cure both diseases
(Picture for illustration purposes only).

For many years, many research groups have found positive side effects of HIV-inhibiting inhibitors. ' We find that these enzymes have antimalarial properties, ' Sinnis said.

Researchers believe HIV-mediated inhibitors may also end the presence of proteolytic proteins in malaria parasites, much like HIV inhibitors. Sinnis's team found that anti-HIV drugs successfully prevent recreated malaria parasites in mice.

This test has not yet been conducted in humans, but the initial test results in mice prompted researchers to use resolution inhibitors in HIV treatment for African patients.

'In Africa, where HIV and malaria overlap, the HIV drugs we use must be resolution inhibitors, and then have additional effects to prevent malaria spread ,' Sinnis said.

Currently, new resolution inhibitors are used to treat malaria for people with HIV. This medicine is more toxic than many antimalarial drugs, so it is not given to people who only have malaria. But if resolution inhibitors can be adjusted to reduce toxicity, it will be used for malaria patients.

So far, scientists have limited the enzymes that degrade, which may contain target enzymes, but they have yet to find a specific enzyme. Because of the complex life cycle and gene sequence of malaria parasites, 'it is difficult to express the proteins of the malaria parasite (including enzymes that degrade) in the laboratory. That led to a slow progression of the testing of enzymatic enzyme inhibitors of malaria parasites , "Sinnis explained.

In a paper published by the American Society of Experimental Biology, Colin Berry and his colleagues at Cardiff University (UK) said they found a enzymatic breakdown in the HIV-resolving inhibitor of Leishmania parasites - relatives. of malaria parasites. Although this Dd1 has not been detected in malaria parasites, Berry's team believes that this is the resolution that scientists have long wanted to find.

' Our results show that the Dd1 proteins are targets of HIV-inhibiting agents, and show that the Leishmania Ddi1 is most likely the target of these drugs and is the potential target of antithrombotic therapy. Bioavailability , 'said Berry and colleagues.

HIV, the virus that causes AIDS in the century, kills 2 million people worldwide each year. Malaria, parasites spread through mosquitoes, infect 225 million people and kill 781,000 people each year.