Nucleotic synthesis has hope in treating cancer

Through experiments with animals, Japanese researchers have discovered nucleotides that carry the genetic information contained in the liver to synthesize according to a certain rhythm of their clock c.

Since then researchers hope to develop therapies that combine cancer chemotherapy and circadian clock to improve treatment efficacy.

Nuacleotic is the basic constituent of nucleic acid, along with the distribution of nucleic acids in internal organs, organs and cells in the body, nucleotic also participates in basic life activities such as Genetics, sexual development and growth.

Professor Okamura of Kyoto University, the head of the research team, revealed in US Cell reports that they are conducting animal experiments with mice that are destroyed by biological clocks in the liver and the animals. Normal mice to investigate enzyme changes produced by nucleotides.

The results showed that in normal mice the amount of enzyme produced during the day accounted for about a quarter of the enzyme produced at night, the change in the amount of this enzyme has a parabolic pattern. However, in mice that are destroyed in the biological clock, the change in the amount of enzyme has abnormal disorders.

The change of the enzyme reflects the change in nucleotic quantities. Chemotherapy is a way to change the amount of enzymes produced by the nucleotic to kill cancer cells.

Therefore, researchers believe that in cancer treatment, the determination of nucleotic synthesis rhythm will help select the most appropriate time to conduct chemotherapy, thereby improving treatment results and minimizing side effects.