Detection of proteins related to pancreatic cancer

According to a study published in the journal Clinical Cancer Research in October, British scientists discovered a protein linked to the development of pancreatic cancer.

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In their study, scientists at Barts and the London School of Medicine and Dentistry found that nearly a quarter of pancreatic cancer cells have a high concentration of a protein called P110γ.

In experiments, when the production of this protein is blocked, cancer cells also stop growing.

Professor Marco Falasca, director of the study, said: " There are a large number of patients with high P110γ protein levels. In fact, this protein plays an important role in the development of the disease. . "

Professor Falasca and colleagues examined normal pancreatic tissues and cancerous tissues to detect proteins associated with cancer cell growth. About half of all cancers are associated with a member of a protein family - called Phosphoinositide 3-Kinase (PI3K).

Results from the test experiments showed that high levels of P110γ were detected in about 72% of pancreatic cancer tissues, while the protein was not found in normal pancreatic tissues.

Pancreatic cancer is a common cancer in the digestive tract, it accounts for about 10% of gastrointestinal cancer and about 2% of all cancers. The disease is more common in men than in women, usually after age 60, with risk factors such as tobacco, alcohol, coffee, meat, fat, diabetes .

In general, pancreatic cancer is a type of cancer that is difficult to diagnose, so it is often diagnosed late, so prognosis is often difficult. Pancreatic cancer includes exocrine pancreatic cancer - a common type and endocrine pancreatic cancer - this is less common.

To detect pancreatic cancer early, it is necessary to master the following symptoms: usually only early signs of jaundice, then pain and weight loss; pain spreads from the epigastric region to the back, a slight decrease in pain when the patient leans forward, a few cases of transient pain but increased blood amylase, indicates acute pancreatitis due to tumor blockage; weight loss seen in most patients due to anorexia; Dark urine, itchy skin, clay-like stools.

Other manifestations include: venous thromboembolism and moving venous thromboembolism; Hemorrhage is digested from the varicose veins due to tumor suppressing the portal vein system and enlarged spleen because of splenic veins permeate cancer cells.