Find a way to kill bacteria in a completely new body

American scientists have found a way to create warriors that protect the body's immune system from antibiotics, causing bacteria in the cells to become targets of attack.

Methods to help clean up bacteria in cells

According to the study description, published in Nature, the expert group of biotechnology company Genentech links an antibody to a derivative of a group of antibiotics called rifamycin . It has been shown to be a new way to destroy staph (Staphylococcus aureus) in cells. In the future, we can use this technique to treat cases of abnormal blood bacteria and antibiotic resistance.

Staphylococcus aureus is quite common, often concentrating around the nose. There will be no serious problems unless they cause severe and repeated infections, potentially fatal. Some strains can be naturally resistant to conventional antibiotics, in which MRSA staph infections cause 80,000 infections and 11,285 deaths each year. That's why researchers want to find a way to destroy the pathogen when it is still in the cell, where the antibiotic-resistant staph antibiotic is ineffective.

Staphylococcus aureus is quite common, often concentrating around the nose.

"Staph can hide inside blood cells for hours or days, then thrive and spread to other cells," said biologist Sanjeev Mariathasan. This is a big problem because the drug used to fight infection usually works for about 4 hours, much longer than the time when bacteria spread to new cells. According to Mariathasan, in studies with mice, this animal recovered faster and suffered less from negative effects.

Over the years, Genentech has created antibodies that can counteract foreign agents like staph. Scientists combine antibiotics with antibodies using amino acids as a glue. When combined, the method promises to be more effective than conventional antibiotics.

Gerald Pier, a microbiologist at Harvard University, thinks that the team needs to prove that it also works with many different strains of bacteria. Researchers have not yet been able to conclude whether cell staph is the cause of repeated infections, but this method may put an end to the cleanup of bacteria.

However, the study still has some limitations when experimenting only with mice and cells in vitro. Mariathasan refused to reveal the timing of the experiment, but he said Genentech was very interested in the results for humans. Since this is a special medicine, doctors will only use it when the patient has been carefully diagnosed.