Gene therapy helps aging the heart

The above gene variant is related to cell development, opening new prospects for cancer treatment.

Experiments by Japanese scientists show that cardiac aging can be prevented by influencing the variant of the P13K gene - the gene involved in insulin signaling - on a group of old mice, which opens. New perspectives on the possibility of applying this research to control degeneration of the human heart. The study was published in the American Circulation journal on October 12.

According to Dr. Tetsuo Shioi and colleagues at Kyoto University, the variant of the P13K gene, called p110alpha isoform, plays an important role in tissue aging and when blocking its activity, its function Heart activity is stronger.

Since then scientists hope to develop new gene therapy to treat aging-related heart failure - the common condition is that the heart is unable to pump blood to the body. On the other hand, the gene variant above is related to cell development, opening up new prospects for cancer treatment.