Genetic research shows the relationship between dementia and deformities

The relationship between dementia and heterosexual disease is because the brain-processed starch protein has finally been confirmed, which is an important step forward for effective drug therapy for the patient.

Dr. Peter St George Hyslop (Photo: cbc)

Often harmless, starch protein precursors are considered to be activated for the destruction of the nervous system when they are broken down and deformed into a toxic form of beta starch. Previous studies have shown that people with dementia have reduced their level of protein processing.

To find out whether these low-level proteins can produce toxic beta starches, Dr. Peter St George-Hyslop of the University of Toronto Canada and colleagues studied DNA of 6,861 people, accounting for 46 % of people with dementia.

The study has demonstrated mutagenic cases in SORL 1 gene, which creates a protein and protein that binds to starch and passes it to a place where the cell is regenerated. harmless.

To show that mutations in SORL1 can activate the disease, the researchers conducted a gene inactivation experiment on the cell. They found that this greatly increased the production of toxic beta starches. Professor St George-Hyslop said: "In places where SORL 1 is not available or incomplete, it will allow starch to drift into other areas and there it will degenerate."

The team identified two areas of SORL 1 as a shelter of the mutagenic disease, but they have yet to find a malformed SORL 1. When doing the experiment, they hoped it could lead to a drug that increased functional activity in humans by gene variants.

Anh Phuong