Infertility due to immunity

American scientists have discovered clues that cause immunity due to immunity - a little thing to be said. In people with this disease, their immune system attacks the sperm, reducing fertility.

Pollutants, stress and other negative factors in modern life have contributed to increased infertility rates. That almost everyone knows. But what few people have heard of is immune infertility.

As one of 80 discovered autoimmune disorders, immune infertility occurs in both men and women. In people with this disease, their immune system attacks the sperm, reducing fertility.

Researchers from the University of Virginia Health System have discovered a protein called RSP44 that stimulates the immune system to attack sperm. RSP44 is available in all males and is located in the tail part of the sperm, in the central part of a section called axoneme, ie the central bone structure consists of 11 microtubules, which determine the movement of sperm .

Researchers have discovered RSP44 protein - located in the sperm's tail - capable of provoking the immune system to attack sperm, causing immune infertility.(Photo: files.turbosquid.com)

In the blood of infertile men, the team found that RSP44 antigen produced the synthesis of anti-sperm antibodies (ASA). However, according to Dr. John C. Herr, director of the Center for Research on Contraception and Reproductive Health, 'not everyone is affected by this antigen'.

Dr. Jagat Shetty, lead researcher, said: 'In some individuals, RSP44 antigen is a useful biomarker of anti-sperm response. That shows there are mechanisms for infertility that we have not yet discovered. '

In women with immune infertility, ASA is present in the reproductive tubes and kills sperm by making the cohesion stick together and puncture the sperm membrane. At the same time, ASA also neutralizes receptors that help sperm meet eggs to conceive.

12% - 15% of infertility cases in women are caused by ASA, and in rare cases, ASA can cause hypersensitivity shock in women after fertilized eggs.

Immune infertility in men can arise from many causes, including vasectomy surgery. After the vas deferens, the remaining sperm in the vas deferens will be "digested" by ASA . ASA may exist for many years in the blood of vasectomy men. Therefore, even if the vasectomy has been resumed, many people can still suffer from ASA impairment of fertility.

According to the research team, therapies such as sperm washing (sperm washing) and egg cell spermatozoa (ICSI) can be applied to treat patients affected by ASA.

Dr. John C. Herr, director of the Center for Research on Contraception and Reproductive Health, said: 'The new discovery on RSP44 will contribute to expanding scientific knowledge of immunity due to immunity and improving performance Results in the diagnosis of reproductive disorders in some men '.

Quang Thinh
According to Softpedia, Medical News Today, Science Daily, VNN