New breakthrough to cure AIDS

The AIDS century will soon be overpowered with a hybrid virus from recombinant methods, which can lead to a breakthrough in how to kill, or at least give better treatment results.

One of the biggest obstacles in the fight against AIDS is the resistance of HIV, mainly to HIV hiding in cells. But with the hybrid virus RT-SHIV, born of combining HIV patterns with another virus, it is possible to detect hiding places as well as how HIV hides in the body .

Breeding virus

To create the RT-SHIV virus, the researchers paired a genetic piece of HIV-1 - the main lineage of HIV - into the genome of SIDV (simian immunodeficiency virus: a virus that causes immune defect in monkeys. , similar to AIDS in humans) and replace about 1/10 of its genome. These additional gene fragments make RT-SHIV's enzyme the target of an antiretroviral synthesis therapy.

' RT-SHIV virus and its' homology' in monkeys combine to form an immune model similar to the way our bodies respond to HIV - virologist Vineet Kewal Ramani at the National Institutes of Health America, explained. This model gives researchers the ability to test the effectiveness of therapies - a method that can be dangerous when tested on humans . '.

Unlike other viruses, the special feature of RT-SHIV is its dual-stream ownership. In tests on macaque monkeys - a commonly selected primates - hybrid viruses can also replicate to cause disease similar to AIDS in humans; and the new pathogen can also tolerate the addition of many antiretroviral drugs - a combination therapy that is being used to treat HIV-positive people.

'Drive' CD-4

Cells infected with HIV

RT-SHIV will bring a great scientific meaning. According to Professor Robert Siliciano at Johns Hopkins University, antiretroviral combination therapy has been expected to expel HIV from the body, but in fact, when patients stop taking drugs, HIV quickly recovers.

Many researchers, such as Siliciano, have made efforts to lift the veil of hiding HIV. A lair may be a group of immune cells called CD-4, and this lair is easily erased with 'model' RT-SHIV. Like HIV, this hybrid virus also creates protective films when attacked by antiretroviral drug combinations .

Scientists inhibited RT-SHIV in infected monkeys with antiretroviral synthesis therapy, thereby examining tissue and cell types that the virus hid. ' This district in the monkey has been identified, and hope is similar to that of humans - Siliciano said. And no one will be cured of AIDS without the hidden hideout of HIV . '.

Trick therapy

The main risk for AIDS patients is that HIV can adapt to drugs after a period of treatment, even becoming neutral with different types of drugs. ' But creating resistance is really difficult for laboratory studies, when the lab environment is completely different from the warm environment on humans and animals . - virus expert Paul Bieniasz of the AIDS Research Center Aaron Diamond said - Some clinical trial drugs failed after showing promise in laboratory cells . '.

RT-SHIV breakthrough also proves the success and safety of new generation of HIV-specific therapies. And, this kind of 'mimic virus' can lead to a trick, hoping to produce future synthetic therapies .'.

Dao Hung