Successfully tested the anti-obesity vaccine

A new anti-obesity vaccine by restraining hormones that stimulate ghrelin appetite, leading to reduced intake of food and increasing calorie consumption in mice, has been studied successfully.

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The results appear in a new study presented at the 93th Annual Endocrine Science Conference in Boston.

The research leader, Associate Professor, Dr. Mariana Monteiro of Portugal's University of Porto said: ' The anti-ghrelin vaccine can become another therapy to treat obesity, used by combining it with diet and exercise. "

Ghrelin is a gut hormone that stimulates weight gain by increasing appetite and absorbing food while reducing energy consumption. Recent research shows that weight-loss surgeries like gastric bypass inhibit ghrelin hormones.

Ms. Monteiro said: 'This shows that there is a hormone mechanism behind weight loss through surgical procedures.'

Monteiro's team has developed a therapeutic vaccine that uses non-infectious viruses carrying ghrelin, to stimulate the immune response - the development of anti-ghrelin antibiotics - that will inhibit this hormone. After that, they vaccinated normal weight mice and those who were obese three times. Next, they compared these mice to controlled uncles, who only received saline injections.

The team said that compared to control mice, mice that were vaccinated, both normal and obese, developed an increased amount of anti-ghrelin antibiotics, increased energy consumption and reduced the absorption of food. eat.

Monteiro said within 24 hours after the first vaccination, obese mice ate 82 percent of the mice 'unvaccinated feed, and after the last vaccination the number dropped to 50 percent.

According to Ms. Monterio, the effect of each vaccination lasts two months while the average life span of mice is 18 months, equivalent to about 4 years for human life. The team said they did not see the effect of any toxin in mice due to the vaccine.

Ms. Monterio said: ' The anti-obesity vaccine in mice also showed the ability to reduce NPY, the most potential signal that increases appetite in the central nervous system. This suggests that ghrelin vaccines reduce brain signaling. '