Technology of gene regulation transplants for obesity

The biggest barrier for those who want to diet to lose weight is hunger. When cravings appear and the eater is forced to find all kinds of ways to ignore the stomach's "lament" - something that's not easy to do. Thus, biologists at the Swiss Federal Institute of Technology ETH Zurich have developed a gene therapy that in the near future could end the suffering of appetite people.

Unlike invasive therapies such as laparoscopic laparoscopic ligation (LAGB) , the new gene therapy developed by the ETH Zurich can be implanted in a capsule. The capsule contains implanted cells with a complex regulatory circuit. This circuit is made by combining proteins that produce proteins and human reactions.

When released, the regulatory circuit continually monitors blood cholesterol levels and when it detects a high concentration, it releases a hormone that makes the body feel full, thereby suppressing the appetite. Researchers say the gene circuit can measure many types of fats, including many types of saturated / unsaturated fats from animals or plants absorbed by the body.

The research team led by Professor Martin Fussenegger tested gene regulation circuits on an obese mouse and is being fed with fatty food. The capsules containing regulatory vessels were transplanted into mice and obese mice stopped eating much, started losing weight. After the blood fat level returns to normal, the regulatory circuit stops secreting saturated substances.

Fussenegger said: 'The mouse has lost weight even though we have consistently given it many calorie foods. ' Although the study will take years to apply to humans, Fussenegger thinks that The gene network transplant may one day provide an alternative to surgical techniques such as liposuction or stomach tightening for people who are obese.