The ability to heal the wound of old oxygen

New information about clarifying how skin cells and tactile nerves combine to regenerate them during wound healing. Researchers at UCLA found a chemical signal released by damaged skin cells that catalyzes the regeneration of tactile nerves, helping to restore the feeling of skin contact after healing. They also discovered that activated oxygen - hydrogen peroxide (or oxygen) has a high concentration in wounds , which is a major component of this signal.

The study, published in PLoS Biology, was tested in striped plaited larvae, a widely used experimental model for understanding the development and regeneration process. This type of transparent larva allows recording images of sensory strings in live animals and determining their regeneration.

Identifying tactile stimuli, such as pressure, temperature, and toxic chemicals, is captured by peripheral sensory nerves that form networks under the skin. When damaged, skin cells proliferate and locate to fill the wound, and peripheral sensory nerve fibers distributed in the skin must also be regenerated to maintain sensory function. Experiments in amphibians and chickens indicate that damaged skin catalyzes the regeneration of peripheral nerves, but the compounds of this effect have not been detected. Hydrogen peroxide has long been known to be a toxic product of cell destruction, but only recently has it been highly appreciated when at low concentrations it can activate certain molecular interactions to help regulate cell growth. Does hydrogen peroxide play a role in the unexplored regeneration of peripheral nerves?

To test whether skin lesions promote the regeneration of nerves, Rieger and Sagasti removed the tail end of the plaited larvae and used time-lapse fluorescence microscopy (intermittent time). Monitor the reaction of tactile nerves near peripheral areas. The removal of the tail promotes the growth of nerves and allows them to spread throughout the skin and still prevent them. They also found that destroying skin cells anywhere on the body also regenerates nearby tactile nerves; This explains that damaged skin cells are the signal source . Adding hydrogen peroxide to the environment of healthy larvae also triggers the promotion of nerve growth as it destroys skin cells. On the contrary, obstructing the production of hydrogen peroxide will prevent the ability of the damaged skin cells to promote nerve regeneration. This result explains that hydrogen peroxide released by necrotic skin cells is a major compound that signals nerve regeneration.

" The study raises some interesting questions about the role of signaling hydrogen peroxide between damaged skin and nerves ," said Sagasti. ' Is hydrogen peroxide directly identified by nerves? or does it cause a secondary signal from the keratinocyte, or does it alter the extracellular environment to promote the growth of nerves? The answer to these questions can provide treatment options to improve the ability to heal damaged skin, which not only ensures integrity of the skin but also restore the sensory function of the skin.