Bacteria in cow's milk cause Crohn's intestinal disease

One out of every 800 people in the UK has Crohn's disease - chronic intestinal inflammation that causes pain, intestinal bleeding and diarrhea.

A team of researchers has discovered that a bacterium called Mycobacterium paraberculosis releases a molecule that causes white blood cells to not kill the body's E. coli bacteria. Among people with Crohn's disease is growing, E.coli bacteria are present in infected tissue.

Mycobacteria are thought to enter the body through cow's milk and other dairy products. It can cause very dangerous diarrhea called Johne in cattle. However, up to now, the mechanism of causing intestinal inflammation in this type of bacteria has not been clarified.

(Artwork: Medseek.com) Professor Jon Rhodes, a University of Clinical Sciences explained: 'Mycobacterium paratuberculosis is detected in tissues with Crohn's disease, but its impact on the disease is still causing. argumentative. We have now demonstrated that this bacterium releases a complex type of sugar containing sugar - called mannoza. This molecule inhibits macrophages, which prevent them from killing E. coli bacteria.

Scientists have also shown that cases of Crohn's disease have a much higher number of E. coli bacteria, and their ability to resist this intestinal bacteria is also lower. The inhibitory effect of the molecule released by Mycobacterial on white blood cells causes people to think about a mechanism that weakens the body's resistance to bacteria.

Professor Rhodes added: 'We also found this bacterium to be an agent causing the appearance of a circulating antibody protein in two-thirds of Crohn's patients. This is a sign that the patient is infected with Mycobacterium '.

The team is testing clinical measures to determine whether antibiotics can be used to kill bacteria in the white blood cells and treat Crohn's disease.