Cooperation in human genome research

In fact, for every group of more than 3,000 people, at least one part of their individual genome is arranged in a sequence, so it is advisable to investigate the study of individual genomes. , scientists' understanding of the role and real meaning of differences in individual genomes is still very limited.

Scientists, working at the University of California, Berkeley, USA, argue that it is the aspirations to explore, expand the knowledge of personal genetics, that have created the impetus for new initiatives to underpin develop a pioneering software that helps analyze individual genome differences and provide a good perspective in the future, when an individual's genome will be the starting point for advice on health and health issues.

' What we have now is a collection of many different incompatible databases, and there is no common infrastructure for analyzing and integrating genetic variants ,' says Steven E. Brenner, professor of genetics, works at the Center for Computer Biology, UC Berkeley University, USA. ' We are focusing on building a solid foundation, to identify the genetic characteristics and fundamental sources of disease, moreover, this is a valuable source of genetic information about the disease. disability and treatment ability, which doctors can use to inform or explain to their patients . '

This initiative was launched in 2011 with an initial grant of $ 900,000, within four years, as part of a partnership program with Tata Consultancy Services (TCS), a trading company. Global IT solutions and services, headquartered in India. In addition to funding this project, TCS will support specialized software for this research work, through the company's global Innovation Labs, to work collaboratively with scientists and work At UC, Berkeley, USA aims to accelerate the progress of the project. This collaborative program will bring practical results through exchange of ideas and research collaboration among scientists working at TCS and UC, Berkeley, USA. A total of 3 to 4 million dollars is spent by TCS on UC, Berkeley, and the United States to implement this project.

' TCS is proud to support and stand side by side with UC, Berkeley, and the United States in shedding light on the role, the true meaning of differences in individual genomes, to bring about benefits. practical in diagnosing and treating diseases. The partnership with the University of Berkeley, California is an example of the outstanding success of the TCS 'successful Co-Innovation Network (COIN) program with educational institutions. Researchers, coming from TCS Innovation Labs, in Hyderabad, India, will work together and work hard with colleagues at UC University, Berkeley, USA . According to K. Ananth Krishnan, vice president and chief technology officer of TCS. ' Health care is an important research topic at TCS and this project will certainly have a major impact on molecular and biological medicine. '

The Center for Computer Biology (CCB) is one of the initiatives included in the UC Berkeley University's scientific development strategy, which includes more than 35 members who are lecturers from 9 faculties, including: students Molecular and cell learning, mathematics, computer science, biology statistics and plant biology and bacteria. The main goal of the Computer Biology Center (CCB) is to explain the calculation of changes in the human genome.

'Although the sequencing of 1,000 genomes will take about 2-3 years, and although very few genetic variants of humans can be fully explained to the meaning of birth. Its learning, the lecturers of the Center for Computer Biology (CCB) still believe this is: great success in studying the human genome in this century , 'according to Lior Pachter, director of China. Computer Biology (CCB), and is a professor of mathematics, molecular and cell biology, and electrical engineering and computer science, working at UC University, Berkeley, USA.

'This project will leverage the talents of the computer science center, model systems and experimental biology, to solve a major problem today, how to evaluate genetic mutations and predict their impact, 'said Lior Pachter. ' TCS has contributed very strong human and financial resources to this effort, revitalizing this project through its technical advantages, global consulting and transfer services related to the development of compilers. We are very pleased and excited with the cooperation between UC University, Berkeley, USA and TCS company . '

' Some people have questioned the practical medical significance of a human genome research project ,' notes Mark Schlissel, Dean of the Department of Biological Sciences, working at UC Berkeley's College of Letters & Science. . ' Critics do not realize that these are still early days. The ability to collect data about our genome has increased faster than expected. The genetic modification compiler at UC, Berkeley, USA, represents a huge step forward in the study of the human genome, applied to human health care. '

New projects will initially focus on building compilers that target the individual human genome sequentially in order to unify the database for the future. Brenner predicts that TCS's support will allow research groups at UC, Berkeley, USA, to first build a control compiler, which will integrate more modules. . The entire project will create open source software, so that the scientific community can use, test, share and refine.

' Nobody has a monopoly on all the good ideas to explain the meaning of genetic variation and its possible effects, so we hope to create a system that will allow ideas Good idea has a chance to sprout , 'said Jasper Rine, former director of CCB, a professor of cell and molecular biology who plays a role in establishing cooperation with TCS. 'People will be able to test their ideas, parallel or compete against others to find out which applications are best for that purpose .'

The work began, with Brenner, Pachter, Rine and others at the meeting at the computer biology center with TCS engineers, to outline a design that underlies software.

' Universities can play a very important role in basic research in the field of molecular biology to help us understand all genetic variations ,' according to Pachter. ' But outside investment is the key to developing an open source software platform for all researchers, no matter where they work, in academia or industry, all Can be easy, continuous access. TCS is the first company and we hope to have more companies to sponsor, and make practical contributions to this open source software . '