For the first time, Vietnam has successfully built the Vietnamese genome

Dr. Le Sy Vinh, lecturer of the University of Technology, Chairman of the National University of Hanoi's key research program on Biology and Pharmacy, said that the group had the first results on genetic research and construction research. Vietnamese people, starting from the approach of computerization - birth calculation techniques.

The group received the genome data of a Vietnamese individual in late 2013. This data includes more than 108 billion nucleotides.

On that basis, the research team has built and analyzed the genome of this Vietnamese individual with modern and highly accurate calculation methods and technologies, implemented on the computer system of University of Technology, VNU and Hanoi University of Technology.

The results of the analysis were compared with the standard genome of humans and found that almost all of the standard genome of humans is covered by this Vietnamese individual genome data.

Dr. Clearly, the genome data of the Vietnamese individual was captured by the new generation Illumina HiSeq 2000 sequencing machine with high coverage (34 times) similar to the 30 times coverage in the project. Human genome project of other countries at BGI-Hongkong Sequencing Center.

The genome of this Vietnamese individual contains more than 3 million single polymorphisms (SNP) compared to the human reference genome. Many changes are new and found only in the genome of Vietnamese individuals. The analytical results also uncover some other new changes related to the structure.

Genetic research is the breakthrough of the 21st century

The human genome, which consists of more than 3 billion nucleotides, carries all genetic information that determines the shape, health and development of humans. The standard genome of humans was basically built in 2001 at a cost of about 3 billion USD and carried out within 15 years. This is considered one of the most important scientific breakthroughs in the 21st century.

The research team consists of 13 people, who are lecturers, fellows and students of the University of Technology, Hanoi University of Technology, Vietnam Academy of Science and Technology and Oxford University.

Previously, research and application of human genomes was only the work of rich countries. Currently, the new generation of low-cost genome sequencing technology has formed, turning the dream of studying and developing products related to the human genome of many countries into reality. Currently, about 20 countries have successfully built and analyzed their own genomes.

Some outstanding projects such as the 1000 human genome project in the world started in 2008, the 750 Dutch project to solve the order at BGI-Hongkong started in 2011, one million Chinese people started in 2011, or Korea's first one-gen genome project in 2009, Japan in 2010.

In the project of 1000 human genomes, raw data (only with 4-fold coverage) of 100 Vietnamese people were posted online in mid-2013.

Dual benefits

The development and analysis of the human genome has a great impact on many different areas, including prominence in medicine, pharmacology, biotechnology and anthropology, while promoting the development of the economy. of nations. Especially as genetic analysis studies to provide early warning, prevention and treatment, develop individualized treatments and treatments.

According to the company's research report 'Battelle Technology Partnership Practice,' for the past 10 years, the human genome has created an economic value of about $ 796 billion for the United States.

Compared to the total cost of US $ 5.6 billion invested in 2010 to study and improve the human genome, economic returns are impressive (141 times higher). This is one of the investments that has brought about the biggest economic impact ever of the United States.

The construction and analysis of a single Vietnamese genome of the research group led by TS. Le Sy Vinh leads the way, showing that Vietnamese scientists have begun to master the process, as well as modern calculation methods to gradually implement projects related to the genome in general, and the human genome. in particular.