Detection of the p53 gene inhibits the growth of cancer cells

Researchers working at Hebrew University, Jerusalem, Israel, have discovered: The mechanism of cancer cell development, this new discovery can help detect and treat cancer effectively. than.

Researchers have discovered the mechanism of action of cancer cells, which the researchers say has never been known before, thanks to this mechanism, tons of cancer cells normal tissue, spreading the cancer to different parts of the body.

The ability to invade the adjacent structures of tumor cells is a prerequisite for the distinction between: the metastasis of malignant tumors with benign benign tumors. Therefore, understanding the mechanism of spread of malignant cancer cells, to find effective measures and remedies to prevent the spread of malignant cancer cells, facilitate early detection. and effective treatment of cancer.

The previous concept was that: Tumor cells spread due to the accumulation of gene mutations, and each of these gene mutations equipped with the properties that spread to cancer cells.

But now, Professor Yinon Ben-Neriah and Dr Eli Pikarsky, work at the Israel-Canada Medical Research Institute, the Faculty of Medicine, Hebrew University, Israel and colleagues have discovered a completely different mechanism. through which tumor cells are equipped with spread properties. The researchers found that this mechanism is operated by a combination of a group of genes, when they activate each other to assign invasive properties to epithelial cells (such as cells lining the digestive tract, sugar. Respiratory, urinary tract .) The results of this study were published in the journal Nature .

Doctor Eli Pikarsky (left) and Professor Yinon Ben-Neriah

Interestingly, it was discovered that: a single gene capable of inhibiting the activation of the entire group of genes, which is the p53 gene , is considered the gene capable of inhibiting the most important cancer, Unfortunately, the p53 gene is inactive in most human cancers . Some of the key features of protein produced by the p53 gene are: inhibiting cancer cell growth and detecting dead cells, this is a previous discovery by Dr. Moshe Oren, working at Weizmann Science Institute, and another member of the current research team. These properties are considered a reasonable explanation for the main activity of the p53 gene in inhibiting cancer cell growth. However, the new study is currently describing the nature of another mechanism in p53 gene activity: that is to inhibit the spread of cancer cells, which can lead to finding a Extremely effective new method of early detection and treatment of cancers: colorectal cancer, colorectal cancer and other types of carcinoma.

Two graduate students, Ela Elyada and Ariel Pribluda, belong to a group of researchers working at Hebrew University, Jerusalem, Israel, who have developed research models on experimental mice, through this model, they have can demonstrate genetic modification that causes invasion of cancer cells and the way in which p53 gene can inhibit that process, when the p53 gene is activated.

The results of the new study are very important in helping to detect and treat cancer more effectively.

The discovery of new genes can activate cancer cells to develop, effective in diagnosing biological signs to distinguish: benign tumors are harmless to malignant tumors, as well as to help Early detection of metastatic cancer cells. This difference is an important element of treatment options, making a decision to treat at the present time completely based on micro studies on newly discovered genes. This rapid and accurate diagnosis at the molecular level, helps to identify benign tumors or malignant tumors, assesses the therapeutic effect of drug treatment, the life of cancer patients. can be saved by choosing the right treatment and early detection of cancer right from the beginning, especially doctors can follow the cancer treatment process properly while keeping it secret Health status of cancer patients in serious cases.

The results of this study also showed new measures to maintain p53 gene activation as an effective protection, preventing the epidermal cells from transforming into malignant cancer cells.

The study received funding primarily from Dr. Miriam's Medical Research Foundation and Dr. Sheldon G. Adelson and the Israel Science Foundation.