How accurate is the DNA test for the biological child?

Parental DNA testing is done by comparing the baby's personal DNA information with the DNA of the alleged biological father.

Dr. Bui Dac Chi, Department of Genetics and Hematology, Medic General Clinic explained, DNA test is a DNA analysis (Deoxyribo Nucleic Acid) in the body's cells to determine the relationship. bloodline between subjects.

According to genetics, 23 chromosomes in the mother's egg cell and 23 chromosomes in the father's sperm combine to produce the child. These 46 chromosomes are present in every cell of the human body, of which 23 are taken from the mother and 23 from the father. DNA testing allows checking whether the right child takes the DNA from the other father's chromosomes.

DNA testing is the way to verify the most accurate blood relationship today. Parent DNA testing is often needed in cases of adoption, in vitro fertilization or for personal reasons. This test is intended to prove whether a man is the biological father of a certain child. The process is done by comparing the baby's personal DNA information with the individual DNA that the man is supposed to be. Each individual DNA information includes 16 marker genes.

Involvement of mothers increases the accuracy of the results but is not required.

Participants in DNA testing verify paternity including the child and the alleged biological father. Involvement of mothers increases the accuracy of the results but is not required. If the mother's DNA, the child and the father's question are matched in each gene, the blood-related affirmation accuracy is 99.999% to 99.9999%, then conclude that the man is the father of child. In contrast, 2 two DNA samples of the child and the suspect father do not match each other with two or more genes, concluding that 100% of this man is not the father of the child.

In fact, father and son blood tests can be performed without the presence of a mother. If the father's DNA samples are questionable and the child does not match, it is possible to completely eliminate the possibility that the man is the father of the child. If the samples match, it can be confirmed that the man is the real father.

Blood tests can be carried out with a variety of cells such as blood, cheek cells, tissue, nail, hairline, umbilical cord . All have the same accuracy, because every cell is in the same one body has the same type of DNA. The requester of the test can self-sample according to the experts' instructions. This may include saliva, fingernails or toenails, 3 to 5 hair pins (not scissors), umbilical cord, toothbrush, condom and many other objects depending on the situation.

Children can participate in DNA testing since they are not born , so there is no age limit for blood tests. DNA testing can be done with a very small amount of sample, such as using a quarter of a drop of blood or a cotton swab containing cells in the mouth, a small piece of umbilical cord has fallen off. For prenatal testing, amniotic fluid containing 3-month fetal cells may be used.

Usually when a person expresses a desire to assess DNA, a specialist doctor will advise whether this is a genetic test . If you find that you are not eligible for assessment, your doctor may refuse. The time to process test records and receive samples in about 20 minutes. The technical process of DNA testing in laboratories often undergoes the following procedures:

1. Check sample orientation.
2. DNA extract, quantified with Real Time PCR-TaqMan.
3. Amplify STRs through PCR (Polymerase Chain Reaction).
4. Separating amplified DNA sequences through capillary electrophoresis in automatic sequence analysis (ABI 3130, Applied Biosystems).
5. Analysis of amplified DNA sequences using geneeMapper (Nuclear DNA) or SeqScape (Mitochondrial DNA) software.

The time from receiving the sample to returning the result is usually several days to a week. Test results paid to customers usually include Vietnamese and English. All are sealed, confidential, medical staff will hand and explain thoroughly to the requester for testing, not by phone and other indirect forms.