Now what medicine ...

Recently, a new measure has been found when identifying and determining the role of biological cycles in the human body in improving the efficacy of drugs. That is to choose when to use the medicine to make the medicine work best. And that is the research content of a new field of medicine and pharmacy: Chronopharmacologie.

Changes in human biological phenomena occur regularly and continuously, forming a cycle called the biological cycle.

The physical state of the body can be understood as some biological structural disorder that leads to disorder of biological structure over time. And the therapeutic effect of the drug may be considered to correct this disorder.

In contrast, the biological structure over time also influences the effect of the drug. A drug taken into the body, its effect depends on many factors, but mainly due to tolerability (according to folklore, it is "appropriate" or "tolerant") of the body for drugs and Drug metabolism in the body leads to effects.

About drug tolerance (ie, the tolerance of the body to the drug):

If the body does not tolerate the drug well, the medicine will have a bad effect , maybe even poison. Many studies show that the tolerance of the body also changes periodically according to the biological cycle in the body involved. For example, knowing the biological cycle of endogenous adrenalin secretion is at its maximum at 9 am during the day, so it is not beneficial for the body to provide adrenalin at this time. Adrenalin is available. Or as it has been shown, the toxicity of anticancer drugs (ie, the effect of killing cancer cells while also being toxic to normal cells) of 5-fluoruracil is twice as strong in the morning. compared to the afternoon, that is, the body's resistance to this anticancer drug is better in the afternoon.

About drug metabolism:

Many drugs if rapidly metabolized by the body, the effect of the drug will be strong but short. The metabolism is too slow, the effect will be weak and prolonged. Regardless of the slow metabolic situation, it can accumulate in the body causing poisoning. Through research, it has been found that drug metabolism is not always the same but there is a daily cycle change. The reason is that drug metabolism depends on the activity of enzymes called enzymes metabolizing drugs. The enzymes themselves work cyclically and the endocrine system has a great effect on regulating enzymes that also work cyclically.

Thus, it is clear that the effect of the drug depends on the time factor. Taking medication at the right time will work best. Improper use of the drug not only does not cure the disease, but it can also be harmful because it disturbs the body's biological structure over time.

The main research content of Pharmacological Pharmacology is to determine the optimal duration of drug administration for each drug and the optimal dose based on the biological structure over time of the body.

In order to determine the optimal time to use the drug, people pay much attention to the biological cycles of day and night and try to elucidate the mechanism of producing these biological cycles. It is theorized that the glande pinéale is the body that controls the biological cycles. This route has a response to the variation of light caused by external circulation and night from outside. The signal of darkness or light from the retina of the eye following the optic nerve to the pineal gland will stimulate or inhibit the pineal gland to secrete substances that control biological cycles. In these substances, melatonin is a relatively well known substance. It has been shown that, in some animals, melatonin is secreted mainly by the pineal gland at night. Daylight depending on the intensity will reduce or stop the synthesis and secretion of melatonin. Currently, melatonin is used for general insomnia treatment, in which time zone deviation.

When putting drugs into the body, pharmacology of the moment pays attention to three issues:

- Kinetic study (chronocinétique): That is how drugs will absorb, distribute, metabolize, eliminate according to the cycle of time.

- Sensory period (chronesthésie): Ie the response of the target system (where the drug will work) for the periodic drug.

- Active time (chronesgie): Ie the effect of the drug, including good and bad, according to the period of time.

Up to now, many drugs have been studied to choose the optimal time of the day. If you choose the right time for the optimal medicine, you can reduce the toxicity without reducing the dose. It is even hoped that they will use all of the substances previously used to treat cancer but then have to remove it because it is too toxic.

For drug users, care should be taken to use the medication as prescribed by the physician or in accordance with the instructions for use . Not only follow the right medicine but also follow the right way, especially according to the right number of times, at the right time of the day. Therapists constantly improve their knowledge of drug use and according to 'what time it ' is Pharmacological compliance the moment being developed and widely applied today.