What is Celecoxib?

Celecoxib is a non-steroidal anti-inflammatory, analgesic drug commonly used in the treatment of symptoms of osteoarthritis, rheumatoid arthritis in adults. Treatment of acute pain, including postoperative pain, tooth extraction. It is also used in people with primary dysmenorrhea.

The effect of celecoxib

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID), a selective COX-2 inhibitor that reduces pain and swelling (inflammation). The drug is used to treat arthritis, acute pain, dysmenorrhea and discomfort. Relieving pain and swelling will help you get back to normal activities sooner.

If you are treating a chronic condition such as arthritis, ask your doctor for non-pharmacological treatments or use other medicines to treat the pain.

This drug works by blocking enzymes that produce prostaglandins in the body. Reducing prostaglandins helps reduce pain and swelling.

Some uses of the drug are not listed on approved professional labels, but your doctor may prescribe them for use. You only take this medication only if directed by your doctor.

This medicine may also treat gout.

You should take this medicine with a full glass of water (about 240 ml) unless your doctor tells you otherwise.

How to use celecoxib

You should take this medication as directed by your doctor, usually once or twice daily. To reduce the risk of stomach discomfort, this drug is best taken with meals. The dosage is based on your medical condition and response to treatment. Take the lowest dose medicine and only during the prescription

You should take this medicine with a full glass of water (about 240 ml) unless your doctor tells you otherwise. Do not lie down 10 minutes after taking the drug.

For conditions (such as arthritis), you may need to take medication regularly for two weeks to see the effect.

If you are taking it on an 'as needed' basis (not on a regular schedule), keep in mind that painkillers work best when the first symptoms appear. If you wait until the pain gets worse, the medication may not work as well.

Preserving celecoxib medicine

You should store at room temperature, away from moisture and light. Do not store in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should carefully read the storage instructions on the package, or ask a pharmacist. Keep out of reach of children and pets.

You should not throw medication into the toilet or plumbing unless required. Instead, dispose of properly when the medicine is out of date or cannot be used. You can consult your pharmacist or local waste disposal company about how to safely dispose of your medication.

Dosage

Dosage for adults

1. Usual Adult Dose for Pain Relief : If you have acute pain, take 400 mg orally of 200 mg if needed on the first day. Then, take 200 mg orally twice daily as needed.
2. Usual Adult Dose for Menstrual Cramps: The starting dose is 400 mg, followed by 200 mg if necessary on the first day. Then take 200 mg orally twice daily as needed.
3. Usual adult dose for osteoarthritis pain: 200 mg orally once a day or 100 mg orally twice daily.
4. Usual adult dose for rheumatoid arthritis: Take 100-200 mg orally twice daily.
5. Usual adult dose for polyposis adenoma : 400 mg orally twice daily with food.
6. Usual adult dose for ankylosing spondylitis: 200 mg orally once a day or 100 mg orally twice daily. If after 6 weeks of treatment with no results, you can try the dose of 400 mg orally daily. If there is no response after 6 weeks, you should consider alternative treatment options.

Dosage for children

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

1. For children 2 years and older and weighing 10-25 kg, give 50 mg orally twice daily;
2. For children 2 years and older and weighing over 25 kg, give the child 100 mg orally twice daily.

The form of celecoxib

Celecoxib is available in capsule form.

Side effects

You should stop using celecoxib and call your doctor at once if you have serious side effects such as:

1. Chest pain
2. Attenuate;
3. Shortness of breath;
4. Stutter;
5. Vision loss or imbalance;
6. Bloody or tarry stools;
7. Coughing up blood or vomiting like coffee grounds;
8. Swelling or rapid weight gain;
9. Urinating less than usual or not wanting to urinate - nausea, upper abdominal pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
10. Skin rash, bruising, severe itching, numbness, pain, muscle weakness;
11. Severe skin reaction - fever, sore throat, swelling of the face or tongue, eye burns, skin pain, red or purple skin rash spread (especially on the face or upper body) and cause blistering and peeling.

Less serious side effects may include:

1. Stomach discomfort, diarrhea, flatulence, gas;
2. Dizziness, nervousness, headache;
3. Runny or stuffy nose, sore throat;
4. Mild skin rash.

Note before taking celecoxib

You should not use celecoxib immediately before or after heart surgery (bypass coronary artery bypass graft or coronary artery bypass).

This medication can cause life-threatening heart problems like a heart attack or stroke, especially if you use it long term.

This medicine can also cause serious effects on the stomach or intestines, including bleeding or perforation (creating a hole). These diseases can be fatal and may occur without warning before you take celecoxib, especially in older adults.

You should not use this medication if you are allergic to celecoxib or if you have a history of allergy to aspirin, sulfa drugs or other NSAIDs.

There are still not enough studies to determine the risk of using this medication during pregnancy or breastfeeding. Before taking medication, always consult your doctor to weigh the benefits and risks.

According to the US Food and Drug Administration (FDA), this drug belongs to category C drugs for pregnancy. You can refer to the table below for pregnant women:

1. A = No risk;
2. B = No risk in some studies;
3. C = There may be a risk;
4. D = There is evidence of risk;
5. X = Contraindicated;
6. N = Unknown.

Drug interactions

Although some medicines should not be used together, in other cases two different drugs may be used together even if interactions can occur. In these cases, the doctor may change the dose or other necessary precautions. Tell your doctor if you are taking any over-the-counter or over-the-counter (or OTC) medications.

You should not use this medicine with any of the medicines listed below. Your doctor may decide not to treat you with this medication or change some of the other medicines you are taking, especially:

You should also not use this medicine with any of the following medicines, but it may depend on some cases. If both medications are prescribed, your doctor may change the dose or frequency of using one or both medications, especially:

Your medical condition may affect the use of this medicine. Tell your doctor if you have any health problems, especially:

1. Anemia;
2. Congestive heart failure
3. Edema (fluid retention or body swelling);
4. History of myocardial infarction, history of heart disease;
5. Hypertension;
6. Kidney disease, mild to moderate;
7. History of ulcer or stomach bleeding;
8. History of stroke - use with caution as medication can make the disease worse.
9. History of asthma sensitive aspirin;
10. History of aspirin sensitivity;
11. Severe renal insufficiency;
12. Severe liver failure;
13. Sulfamide or sulfonamide allergy (eg sulfamethoxazole, Bactrim® or Septra®) - should not be used in patients with this condition.
14. Heart surgery (for example, coronary artery bypass surgery) - not used for pain relief before or after surgery;
15. Certain inherited diseases (CYP2C9 (hepatic enzyme) metabolism)
16. Mild or moderate liver disease - use with caution because you may need to reduce the dosage.

If you forget to take a dose, take it as soon as possible. However, if it is close to the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take twice the prescribed dose.

Because you will be appointed and monitored by a doctor, pharmacist or other health professional when using the drug, the missed dose is unlikely.