Control the level of development of tissues and blood vessels instead

Researchers have found a way to control the level of development of replacement tissues and the formation of new blood vessels to help solve one of the problems that promote the development of alternative tissues to curing injuries in humans.

This process can be used for bone grafting, tissue replacement, dental treatment, diabetes treatment, or for older patients who are difficult to help with wound healing, according to William Giannobile - professor Michigan School of Oral and Technical College of Dentistry and author of the article. Peter Ma is UM's professor of engineering and dentistry, co-author and an investigator for the National Council's health project.'If you have major injuries your body cannot heal completely, this is a way to increase protein to heal natural wounds,' explains Professor Giannobile.

Researchers implanted platelet-derived growth factors into the nanoparticles and attached them to a lattice-shaped network that could be decomposed by bacteria. In the experiments, the factor restored cells stimulating the body's organs to repair the wound, said Professor Ma. (His laboratory is the site of the development of the above nano-grid and pattern systems).

When tissue grows, it spills onto the grid, which eventually decomposes.

'The growth factor is implanted and secreted much over a period of hours,' said Giannobile, who also manages the Michigan Dental Research Center. 'With some wounds you need a lot of growth factor (growth factor) in the early stages and for some you only need a little for a long time. We have basically found a way to increase or decrease the rate of these growth factors released. '

The platelet-derived growth factor is approved by the FDA for the treatment of diabetic ulcers and bone healing in cases of dental injuries, but the release time is a major difficulty. Professor Ma said the key factor is finding a way to maintain the biological properties of growth factors in nano samples for the purpose of controlling secretion.

The next step is to look at other types of wounds, and then to study the history of human history, Giannobile added.

The research was funded by the National Health Council. Reference: Jin et al. The mesh of nanofibers fused with PDGF-BB microspheres gives Chemokine expression and a new source of tissue in vivo.

Illustrations of nano spheres, integration of nanospheres and nanofibre networks;(A) Microelectronic scans of nano spheres;(B) Enlarged image of the previous (left) and later (right) networks merged with the nano sphere;(C, D) microelectronic scans of nanofibre networks before fusing with nano spheres at 100_ (C) and 10,000_ (D);(E, F) Microelectronic scans of PLLA nanofibre network after fusion with nano spheres at 100_ (E) and 10.00.(Photo: Jin et al.)