Enzyme detection prolongs post-traumatic pain

Scientists have studied experiments in mice and found that brain enzymes cause pain after nerve damage and they hope to use this new enzyme to treat chronic pain in humans.

Image for illustrative purposes. (Internet source)

The findings of scientists from Canada and South Korea published in Science magazine show that they are trying to find a way to reduce pain after detecting this enzyme.

" This finding provides us with a basic understanding of the mechanism of brain activity for chronic pain," said lead researcher Min Zhuo, a professor of physiology at the University of Toronto . It not only creates a new possibility for the preparation of new painkillers but also helps us to know why many drugs do not work to control chronic pain. '

Min Zhuo also said that although pain relievers have existed for a long time in the market, they are used to treat chronic pain such as cancer and end-stage pain relief. there is not enough medicine in the world.

Professor Zhuo and his colleagues discovered increased levels of the enzyme " kinase M zeta protein " in the anterior cortex of injured mice.

To determine the function of this enzyme, they isolated a gene they thought produced this enzyme from another group of mice. In the end, they found that the rats that had the enzyme split underwent little or no chronic pain after the nerve damage.

Professor Zhuo and his team hope the finding will be useful for preparing a new generation of drugs to control this painful long-lasting enzyme.

Zhuo said: ' Currently, many painkillers are not effective for chronic pain, especially neuropathic pain. Therefore, the need for new drugs to effectively control chronic pain is huge . '