Hornet bee venom can kill cancer cells

Other members of the research team also said it would be particularly useful to combine Polybia-MP1 with other drugs, to create a drug that can treat all types of cancer when each ingredient in the drug can impact on a specific part of the cancer cell.

Hornets are too famous for the dangers from their venom-filled stings, though scientists in Brazil and England have discovered an unexpected use of this killer's poison. Wasps: cure cancer. Even the bee's venom only kills the cancer cell and doesn't touch other normal cells.

Giant hornet.

A research team from University of Leeds (UK) and Sao Paulo (Brazil) tested cancer-seeking toxins called Polybia-MP1 found in Polybia paulista bees - a branch of the isp has a lot of bees in Brazil. Scientists have discovered Polybia-MP1 can inhibit many types of cancer cells in prostate, bladder, and leukemia cells that are resistant to many drugs. They found that the Polybia-MP1 molecule could kill cancer cells from the baby but did not damage healthy cells by attacking lipids on the surface of the cancer cell and creating a hole in which the molecules were born. Important learning for outgoing cells.

Specifically, Polybia-MP1 exploits the abnormal arrangement of lipid molecules present in the membrane of cancer cells, which creates gaps in the cell's "defense system" and allows toxins. Break them to destroy from within. In addition, cancer cells targeted by Polybia-MP1 contain two lipid molecules, phosphatidylserine (PS ) - on the outside - and phosphatidylethanolamine (PE) - located on the inner surface - on the membrane where the cells are normal no. These two fats are no different from "pointers" that allow Polybia-MP1 to find cancer cells and destroy them.

Cancer cell.

In order to thoroughly understand the process of destroying cancer cells, two researchers João Ruggiero Neto (Sao Paulo) and Paul Beales (Leed) created membrane layers containing PS, or PE or both types. lipid. They then exposed them to Polybia-MP1 and the results made it all happy that only cell membranes containing both PS and PE make cancer cells easy to destroy, though All membranes are affected after the experiment. Dr. Paul Beales, Ph.D., identified that the polybia-MP1 process that destroys cancer cells can be divided into two phases:

1. First, the toxin will cling to the outer surface of the cell membrane and chisel a hole large enough to allow the cytoplasm to leak out and the Polybia-MP1 molecules will follow this hole to break into the inner cell. cancer cells.The lidpid PS molecule plays an important role in the first stage because the amount of Polybia-MP1 molecules binds to the cell membrane containing PS 7 times higher than normal cells.
2. Then, the Polybia-MP1 molecules will determine the location of PE lipid molecules on the inner surface of the cell membrane and cling to it.They continue to penetrate the cell membrane with holes greater than 20 or 30 times their position.Since then, cancer cells have been destroyed from the inside because even though these holes are created in seconds, they are large enough for important molecules like RNA and proteins to escape from the cell - leading to cell death.

Cancer cells targeted by Polybia-MP1 contain two lipid molecules, phosphatidylserine (PS).

Genetic Professor João Ruggiero Neto said the results of the study will open a new direction for cancer treatments, even though this is the first way to go through the cell membrane with a chemical in it. nature. Other members of the research team also said that it would be especially useful to combine Polybia-MP1 with other drugs to create a drug that can treat all types of cancer when each ingredient in the drug can work. move to a separate part in cancer cells.

At first, Dr. Beales argued that he and his colleagues still needed to dig deeper into how Polybia-MP1 works and make sure that using this toxin does not harm humans. After that, a mouse experiment was conducted and all members of the team were relieved when Polybia-MP1 killed cancer cells and bacteria in mice without harming the cells. other healthy cells. Currently, scientists are conducting research to bring testing soon to the human body and ready for mass production as soon as possible.