Predict the life expectancy of people with heart disease through DNA length

- Can the length of the DNA sequences of patients with heart disease indicate in advance their expected lifespan? Researchers from Intermoutain Heart Research Institute at Intermountain Medical Center, Salt Lake City, have studied DNA of more than 3500 heart disease patients, saying it is possible.

In the new study, the study was introduced on Saturday, March 9 at American College of Cardiology's Annual Scientific Session in San Francisco, scientists were able to predict the survival rate among Heart patients rely on the length of DNA sequences found at the end of the chromosomes known as longer patients' telomeres, the more likely the patient has to live longer.

The study is one of 17 studies by Intermountain Heart Institute at Intermountain Medical Center currently presented at a scientific conference, attended by thousands of heart disease experts and cardiologists from all over the world.

Guess the age of people with heart disease through DNA

Previous research has demonstrated that telomeres' length can be used as a measure of age, but extensive research results show that telomeres can also predict the expected lifespan of telomeres. Heart patients.

Telomeres protect the end of the chromosome from being threatened. As people age, our telomeres will gradually shrink until the cell cannot continue to divide. Short telomeres are associated with age-related diseases, such as heart disease or cancer, as well as exposure to stress-induced oxidation, smoking, air pollution or

"Chromosomes, they are essentially shortened as we age," said John Carlquist, Ph.D., director of the Intermoutain Heart Institute Genetic Laboratory. 'Once they become too short, the function is no longer accurate, signaling the end of life for the cell. And when the cells fall into this state, the risk of patients 'age-related diseases increases dramatically.'

Professor Carlquist and his colleagues from the Intermoutain Heart Center at the Intermoutain Medical Center examined DNA samples from more than 3500 patients with heart attacks and strokes.

'Our research shows that if we sort age statistically, patients with longer telomeres live longer, suggesting that telomere length is not just a measure of age, but can also show the probability to survive. Larger telomere lengths are directly correlated with the ability to live a longer life - even for patients with heart disease , 'Professor Carlguist said.

Professor Carlquist said he believes that in the future, telomere length can be used as a way to assess the effectiveness of heart disease treatments.'We have checked a patient's cholesterol and blood pressure to see how the treatment is working, but this may also give us a closer look at how treatments are working. move to the body and see if the treatment is working. "