Scientists have found a way to completely prevent brain cancer

When blocking the activity of OSMR protein in cells, the tumor did not return.

One of the most dangerous brain cancers, glioblastoma (GMB), may in the future be completely prevented, after scientists find a prerequisite to make them appear. city.

New research published in Nature Neuroscience says a protein called OSMR is playing a role in the formation of a tumor. That means an intervention in OSMR will be able to save thousands of people from brain cancer.

In the future, a dangerous type of brain cancer can be prevented.

Glioblastoma (GMB) is currently one of the cancer with the highest mortality rate. The reason comes from how difficult it is to treat with both surgery and radiation therapy."In fact, most patients with brain tumors survive for only 16 months," said Dr. Arezu Jahani-ASL, a research author from Mc Gill University, Canada. "That's what makes us study this disease."

During the study, the scientists observed stem cells taken from the tumor tumor of a cancer patient. They realized that the previous idea was that any cancer cell could be recreated to become a new tumor not true for brain cancer. In this disease, only certain types of cells are capable of replicating.

Performing experiments on mice with a tumor of GMB, the scientists realized that when leaving some tumor stem cells after surgery, they will quickly recreate into new tumors. But if blocking the activity of the OSMR protein in the cell, the tumor will not return.

"Being able to prevent the formation of tumors is a very impressive and wonderful result," said Dr. Rudnicki, co-author of the study. "It shows us that the OSMR protein is an important part of the puzzle. This may be the goal for future brain cancer treatments."

Stem cells of GMB brain cancer tumor.

Considering the activity of human OSMR protein, the team observed 339 samples of tumor tumors of patients with brain cancer. Accordingly, the more patients have a high manifestation of OSMR, the sooner they die.

In addition, the scientists also discovered an active form of epidermal growth factor receptor, called EGFRvlll , that causes the GMB tumor to form in the brain. Dr. Rudnicki and his team believe that EGFRvlll is bound to the OSMR protein before tumors form. This will also open up hope for methods aimed at breast, lung and uterine cancer with high EGFR expression.

Dr. Azard Bonni, co-author of the study from the University of Washington, said: "The new study opens up an interesting prospect of a new potential target, fighting deadly brain cancer . " The next step, scientists will have to find a way to use a small molecule or antibody to disrupt the interaction between the OSMR protein and EGFR. That will be the future, when GMB tumors are causing brain cancer for humans to be prevented.