Silk containing adenosine promises epilepsy

US scientists are testing tissue grafting solutions in the brains of mice with early epilepsy. Although not completely cure neurological disorders, the results show that this measure significantly reduces the number of seizures in mice.

Seizures due to epilepsy are not only dangerous but also increase the frequency with increasing severity over time. Most patients can control some of the seizures due to medication or surgery, but nearly 30% of cases cannot control the disease.

Photo: transcedo.org

Several studies have shown that adenosine , a natural molecule, has been shown to reduce neuronal stimulation, and has abnormally low concentrations in patients with epilepsy. Therefore, in their study, the expert team of Oregon's Heritage Research Institute, Oregon University of Science and Health and Tufts University in Boston designed a small piece of silk like a decomposing structure. Biologically and completely harmless, with the function of storing and releasing adenosine to limit seizures.

After transplantation, adenosine will continuously release for 10 days and dissolve itself into the body. The results showed that mice with adenosine-containing grafted mice had 4 times less recurrence of recurrence than those without the transplant.

According to scientists, although this solution is safe in mice, it needs to be thoroughly researched to prove safety in humans as well as to determine the optimal dose and duration of adenosine release.