The United States is about to test a vaccine against HIV in humans

Previously, this vaccine has been tested with HIV in monkeys and the results are quite good.

Test HIV vaccine on human body

After 15 years of development, the HIV vaccine against the soon-to-be Robert Gallo, who demonstrated HIV as the cause of AIDS in 1984, conducted tests on 60 volunteers in the first phase of the test. This is historical.

Previously, this vaccine has been tested with HIV in monkeys and the results are quite good. Professor Gallo and colleagues at the American Institute of Anthropology and Microbiology said they could make a turning point in the fight against AIDS with the detection of HIV becoming the weakest in the outer membrane, including The glycoprotein molecules with a molecular weight of 120 kilodantons (KD) are designated as gp120, when the virus binds to the T-lymphocytes of the human body.

When HIV infects a patient, first, it binds to CD4 receptors on white blood cells. It will then relay, revealing the hidden part of its virus shell with the aim of allowing it to cling to the second receptor called CCR5 . Once HIV is attached to these T lymphocyte receptors, it can infect immune cells. At that time, all efforts to stop were too late.

The prototype drug, eCD4-Ig, consists of two components that simulate receptors or anchor points, where HIV attaches to CD4 cells - a key defense of immune cells. The emulator components caught the HIV virus, tricking it into hastily carrying out the mooring process. The virus can only perform this process once, so the simulated components of the drug prevent it from sticking to CD4 cells anymore. Scientists liken this effect to closing the door to the intruder and throwing away the door key.

The team conducted a 40-week trial, which showed that animals vaccinated with eCD4-Ig survived even after four doses of the virus were enough to make them sick. Further research found that short-tailed monkeys "continued to be protected after 8 and 16 doses of infectious virus infection, more than a year after vaccination with eCD4-Ig".

The search for a vaccine against HIV is one of the most important issues in the fight against AIDS in the world. Since 1981, about 78 million people have been infected with HIV, the virus that destroys immune cells and makes the body more susceptible to infections, pneumonia and other opportunistic diseases. About 39 million of them died, according to UN statistics.

Antiretroviral drugs (ARVs) invented in the mid-1990s can treat infections, but cannot cure AIDS or prevent infection with HIV. The treatment of HIV infection now lasts a lifetime and contains many unwanted side effects. For many health systems around the globe, the cost of buying ARVs for people is increasing and becomes a major burden on the national budget.