Transplant human beta cells into mice, cure diabetes

Researchers hope that human experiments in the near future will achieve similar results.

This is the first time researchers have succeeded in converting pluripotent stem cells into beta pancreatic cells . Metabolized cells are implanted in the bodies of diabetic mice and completely prevent the germ of the disease.

Although not yet tested in humans, this initial result is really significant because the lack of beta cells is the cause of diabetes . Scientists just need to find a way to implant this beta cell into the patient's body safely and thus people will not have to worry about diabetes anymore. Unlike current treatment drugs, the method of using beta cells will actually be able to completely cure some forms of root diabetes.

Diabetes alone is a decrease in the functioning of beta cells in the pancreas.

Lead researcher Ronald Evans said: "This finding helps us multiply the number of cells that can be transplanted to patients to the utmost use of cells from patients themselves."

Diabetes alone is a decrease in the functioning of beta cells in the pancreas. Diabetes forms are divided based on the reason for this impairment. You have type 1 diabetes when your beta cells die slowly. When type 2 diabetes is present, this means that beta cells do not perform their original function.

In both cases your body will secrete inadequate amounts of insulin, not enough to guarantee blood glucose regulation. Researchers have long been transplanting healthy cells into infected bodies and now they seem to have actually succeeded (though only in " mouse " patients ).

In their study at the Salk Institute in California, USA, scientists transplanted human beta cells into the bodies of type 1 diabetic mice. They were delighted to observe. The signs of diabetes completely disappear. Although in their experiments, the researchers had to restrain the activity of the subject's immune system to ensure the new cells were not eliminated, when performing this experiment in humans, this would It is no longer necessary because they will use the patient's own stem cells to breed new healthy beta cells.

Human trials will begin in the next few years.

Of course this is not the first time scientists have tried to clone beta cells to cure diabetes, the secret of the success of this experiment lies in the protein called ERRy . These molecules play a role in activating pancreatic cells that produce insulin based on blood glucose like natural beta cells, instead of producing insulin in an uncontrolled way. In addition, this type of cell is cloned using metabolic stem cells from the patient's skin cells instead of being taken directly from the embryo.

What is disappointing here is that the method is not really capable of curing all forms of diabetes. Cases of genetic etiology may recur after a while. Not only that, type 2 diabetes is more difficult to treat than type 1 because the amount of beta cells that fail to perform their function still exists in the patient's body.

Human trials will begin in the next few years and when in operation and will cost not too high.