Dangerous interactions between alcohol and drugs

Alcohol is an organic solvent. The drug is also mostly organic substances, very soluble in each other, creating a suspension that may be compatible or incompatible in the human body.

According to interactive researchers, alcohol interacts with hundreds of drugs and its derivatives. There are many incompatibilities causing many symptoms and diseases such as CNS suppression, respiratory depression, hypertension or hypotension, vasodilation, tachycardia, increased or hypothermia, nausea, erythema , cardiovascular collapse, hepatocellular insufficiency, hepatotoxicity, hypoglycemia, hyperuricemia, liver fibrosis, gastrointestinal irritation .

Depending on the amount of alcohol consumed can lead to clinical symptoms, severe illness can be fatal.

Here are some commonities when taking drugs and drinking alcohol and vice versa :

Antabuse effect: Alcohol causes an abnormal rate of tissue accumulation of acetaldehyde (enzyme inhibition) followed by signs of increase such as vasomotor attack, severe vasodilation, tachycardia, elevated body temperature, nausea, vomiting, skin rash, can cause hypotension, cardiovascular collapse that can lead to death. This effect occurs with the following drugs :

1. Anti-fungal drugs derive imidzol, especially with oral medications (ketoconazole, miconazole, tinidazol .).
2. Biguanides and derivatives of hyperglycemia such as buformin, metformin.
3. Cephalosporins have tetrazol nuclear structures such as cefamandol, latamoxef, cefoperazone, cefmenoxime .
4. Hyperglycemic sulfamides such as glibenclamide, gliclazid, glipizid, gliquidon, tolbutamid .
5. For other drugs such as isoniazid (tuberculosis), griseofulvin (antifungal drug), nitrofural (synthetic antibiotic nitrofuran group), phenicol (antibiotic such as chloramphenicol), procarbazin (newborn cell pliers) are also effective Antabuse response.

Central nervous system inhibition, causing sedation, deep sleep to coma with the following drugs:

Amantadine, antiretroviral drug A2 and Parkinson's symptoms; morphine agonists; 3 round depression medicine; non-barbituric antiepileptic drugs such as sodium valproat; H1 antihistamines ease; barbituric (sleeping pills); benzodiazepines cause sedation, narcotic anxiolytic, anticonvulsant; the carbamate; carbamazepine (epilepsy medication); dantrolen (muscle relaxant); dextropropoxyphen (analgesic); fluoxetine (antidepressant drug); fluvoxamin (non-sedative depression medicine); glutethimid (sedation, sedation); interferon alfa (viral medicine); mianserin (antidepressant drug); medifoxamin (antidepressant medication); methyldopa (treatment of hypertension); oxaflozan (antidepressant medication); primidon (antiepileptic medication).

It can be said to be easy to remember, incompatibility between alcohol (including preparations containing alcohol) and drugs that cause inhibition of the central nervous system to the point of absolute contraindication to narcotic, sedative, antidepressant drugs Epilepsy, antidepressants and H1 antihistamines ease.

More attention must be paid to the operators, drivers, people working high or working in dangerous places, people who need to concentrate their minds and thoughts for the job.

Hepatotoxicity: The liver is an organ that has many functions for metabolism, participates in many mechanisms to maintain and regulate the body's activity to maintain its constant (relative) blood, especially role of body's toxic excretion.

Alcohol, itself is an enemy of the liver, if used simultaneously with imidazol derivatives, especially with ketoconazole (antifungal), the risk of hepatotoxicity is very high, with biguanid derivatives (antidiabetic drugs). sugar) causes liver cell dysfunction. Most of the above antabuse-causing drugs are also toxic to the liver. In addition, methotrexate due to the combination of side effects is very toxic to the liver, causing liver fibrosis, with high and long-term paracetamol to increase the toxic metabolite to the liver.

Excessive hypoglycemia: Especially fasting alcohol while having biguanides (metformin, buformin .) hypoglycemic sulffamides (see above), especially insulin will cause severe hypoglycemia manifest sweat, dizziness, palpitations, hunger, tremor, tremor, restlessness, numbness of hands and feet, tongue, lips, dizziness, headache, drowsiness, blurred vision. May be unusually heavy, can lead to coma, seizures and the risk of death.

Hypotension: Alcohol with morphine agonists not only inhibits central nervous system, sedative, respiratory depression but also lowers blood pressure. Nitrate derivatives such as nitroglycelin and antihypertensive drugs that cause vasodilation, anti-angina all reduce excessive blood pressure. With guanethidin causing orthostatic hypotension, it is possible to fall, with viloxazin, nicorandil not only causes lowering of blood pressure but can also lead to very dangerous shock.

Gastrointestinal toxicity: Alcohol itself is toxic to the stomach. It is a mistake that some people take aspirin to solve their intoxication. Please note that salicylate derivatives (such as aspirin) in alcoholic environment will cause gastrointestinal irritation leading to bleeding. With colchicine, a specific drug to treat gout, along with alcohol, is not only toxic to the gastrointestinal tract but also reduces the therapeutic effect along with hyperuricemia.

Many other drugs should be avoided concurrently with alcohol such as vitamin K anticoagulants (reduced effect), with etretinat causing hyperlipidemia, with non-selective monoamino oxydase inhibitors causing synergistic inhibition CNS, with halogen evaporation drugs causes antagonistic effects of sleep .

Above is saying incompatibility between drugs and alcohol but 'clean' alcohol . But if you use 'dirty' alcohol , alcohol has many impurities such as ketones, aldehydes, volatile substances, especially methanol and other strange substances that make it so harmful that the danger will be multiplied.