Detection of genes that control the body of vaccine responses

Recently, Australian scientists have identified a gene called "Dock8" that controls the body's response to the vaccine.

This is an important finding contributing to increasing vaccination effectiveness as well as improving treatment after transplantation, enhancing autoimmune and anti-allergy.

Clinical immunologist at the University of Canberra, Dr. Katrina Randall, said previous studies have shown that vaccination works to protect the body against disease, but its mechanism of action is Which is still unclear.

Some people have problems when the body does not respond appropriately to the vaccine. Therefore, scientists have conducted research on genetically modified mice.

The results showed that these mice responded very well after first vaccination and produced antibodies. However, a few weeks later, when the test was done, the antibodies completely disappeared. After the study, scientists discovered the "Dock8" gene mutation that caused the phenomenon.

Dr. Randall said that in normal mice, the vaccine will interact with white blood cells called B cells (immune cells) to create antibodies to develop into a protective army.

However, the genetic modification "Dock8" prevented the interaction process.

Experts say the study will help scientists study and prepare more effective vaccines, especially for people who cannot get an immune response to vaccines.