Hormone anti-aging can shorten the life of people

Hormone replacement therapy for anti-aging may not be as effective: it will shorten instead of prolonging human life.

In an ongoing study with older people, people in their 90s with naturally low growth hormone levels were more likely to live up to 100 years of age than those with higher than average growth hormone levels. .

In other words, using growth hormones to fight aging will have the opposite effect, because it will destroy the body's natural defense mechanisms against diseases of old age , researchers of the College of Medicine Albert Einstein (New York) said.

The multi-billion dollar hormone therapy industry was founded on a simple hypothesis: many hormones in the body will decrease in volume when entering middle age, thus adding hormones will help look, even they themselves feel young.

The main hormones used for anti-aging are human growth hormone (HGH) , which stimulates the body to produce another insulin - like hormone IGF-1 and DHEA , the precursor to estrogen and testoterone.

Anti-aging hormones cause reduced life expectancy.(Photo: livescience.com)

The hormonal industry was enraged when a medical study in the New England daily in 1990 talked about 12 men over 60 who were injected with growth hormones. Their muscles and bone density develop to a certain extent, while the amount of body fat decreases. Some businesses understand this is against aging, and that's how they see this study ever since.

However, this method entails many side effects and countless things cannot be determined. Research author, Dr. Daniel Rudman confirms to the point that his research does not mention anti-aging.

In 2003, the New England daily published an article criticizing the anti-aging industry, citing Rudman's research as too obvious in his ad.'If people are persuaded and believe in the use of growth hormones to combat aging on the basis of research published, they have been cheated ,' the article wrote.

The supply of human growth hormone is illegal unless the patient has low levels of this hormone; however, this diagnosis is subjective, so private clinics can recommend this treatment for those who do not need it.

Previous studies have shown that using HGH, estrogen and other hormones can cause cancer, cardiovascular disease, arthritis and other diseases. The new study also found that low levels of IGF-1 could be an advantage, a positive prediction for a longer life.

In the new study, scientists followed 184 men and women in the 90s for 11 years. Surprisingly, their chances of survival during the study depend largely on the amount of IGF-1 in their blood. Each nanogram of IGF-1 on one ml of blood means that they will live longer than about a week.

Low levels of IGF-1 provide benefits for cancer patients. Three years after the start of the study, 75% of the subjects had cancer and low levels of IGF-1 were still alive, while only 25% had ever had cancer and had high levels of IGF-1. be like that.

Earlier, the team of Dr. Nir Barzilai, director of the Institute of Aging Research, found that people who live up to 100 years of age have a gene mutation that helps maintain their body's IGF-1 levels below average. In addition, they also found that mice can live for a long time and do not get cancer when they are not affected by growth hormone.

The new study is consistent with a recent study in the journal Cell Metabolism, which suggests that low levels of IGF-1 are beneficial for middle-aged people. That study found that people aged 50-65 years who ate a lot of animal protein had high levels of IGF-1 that were 4 times more likely to die from cancer and 75% during the 18-year study period.

Dr. Andrzej Bartke, an expert on the effects of hormonal and gene aging, at the Department of Medicine at the University of Southern Illinois, said he was impressed with the new study and said it was "interesting, important and timely". .

However, he also said that the relationship between growth hormone, IGF-1, life cycle and disease is complicated. Some previous studies have shown that low levels of IGF-1 are associated with a high risk of cardiovascular disease. Bartke also noted that study participants had low levels of IGF-1 but also had low blood sugar. This is in contrast to previous studies and may be another factor that explains their long life.

'Growth hormones melt fat and firm the skin, so the appearance improves. It can be used to maintain the so-called 'Hollywood long-term child' but cannot be widely applied to the entire community as an anti-aging therapy, ' said Dr Sofiya Milman, lead author of the study. share.