New drug causes cancer to 'starve'

Scientists have developed a new drug to help block the metabolism of glutamine - the substance needed to grow tumors.

Because glutamine is essential for mass metabolism, the release of JHU083 helps to prevent glutamine, making it more vulnerable. The study was published on November 7 by scientists at John Hopkins University.

The drug acts on the metabolism of tumor cells and tumor microenvironment.

When tested on mice containing colon, lymphoma, and melanoma cells, this pill was shown to significantly reduce tumor growth and improve mouse survival. . The drug acts on the metabolism of tumor cells and tumor microenvironment.

"Targeting glutamine metabolism, we can not only inhibit tumor growth, change tumor microenvironment, but also change T cells with immunotherapy for cancer. letter, " said Dr. Jonathan Powell of the Johns Hopkins Kimmel Cancer Center.

Permanent treatments have been tested on mice, whereby JHU083 plays an important role in triggering the body's immune response to fight tumors.

Moreover, the mice after the cancer treatment will not get new tumors. As can be seen, their immune memory can identify and attack cancer.

Further research showed that the anti-tumor effect was significantly improved when used in combination with JHU083 with PD-1 test-point inhibitor, compared with the use alone.

The scientists also discovered that this compound could increase the effectiveness of nourishing cell therapy, which enhances CAR-T cell therapy to kill cancer cells.

The team is planning to study the effectiveness of combining JHU083 with various types of immunotherapy.

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