Only 1 year left, the HIV vaccine will be officially tested on humans

Vaccine against HIV / AIDS century disease is about to be tested on humans. The eternal future of this disease has arrived.

The problem of the 21st century is cancer, but not so that people take lightly another disease of the century as HIV / AIDS . Scientists are still working very hard to find drugs to treat, or even prevent, the disease before it happens.

And now, according to the latest report from NIAID (National Institute of Allergy and Infectious Diseases - USA), experts have begun planning to test a vaccine against HIV on humans, following successful results with mice. white, guinea pig and monkey. The trial is expected to begin in early 2019.

The anti-HIV vaccine on people to be tested will begin in early 2019.

Specifically, the vaccine will target HIV-1 - an important protein on the surface of HIV, as a virus that helps parasitize the host cell. HIV-1 was identified in 2016, when experts analyzed an HIV antibody caused by infected patients for many years. This patient's natural immune system has created a special antigen, which can be attached to one side of the virus, which in particular is the HIV-1 peptide.

After closer examination, the team led by John Mascola and Peter Kwong were startled to realize that this type of antigen contained all the necessary conditions to help us produce vaccines: both stable when the virus multiplied. copies, are not invaded by other immune cells.

Next, they both tried to make a protein that can stimulate the immune system to produce antibodies targeting the HIV-1 antigen, and then create the corresponding vaccine samples. When tested on mice, the results showed that the antibodies attacked and neutralized up to 31% of 208 HIV strains in the world.

Antibodies (yellow) cling to the viral membrane (gray).The viral spines are green, and the red part is the antigen.

Other tests in guinea-pigs and yellow-tailed macaques also showed very positive results. And that is a sign that the vaccine will work effectively on the human body.

"This study is a very important step towards creating a vaccine against HIV virus," said Anthony S. Fauci, director of NIAID.

The study was published in Nature Medicine.