Only with this technology, cancer cells will
Recently a group of researchers from Harvard Medical University (USA) tested the reprogramming of cancer cells in order to
This method of use not only causes cancer cells to commit suicide but also destroys their fraternal cancer cells.
Recently a group of researchers from Harvard Medical University (USA) tested the reprogramming of cancer cells to "fool" them into turning to each other and killing their own brother cells.
The method of "deceiving" self-destroying each other
Cancer cells often act "to find their way home" - that is, cells that have spread back to the original tumor where they were produced. The team took advantage of this feature of cellular cells, turning their strengths into weaknesses.
Cancer cells often act "back home".
In terms of ideas, the team used CRISPR to put S-TRAIL into cancer cells, a protein capable of destroying cancer cells without harming healthy cells.
The idea of the group is to put "the kill switch" into the cell, causing them to kill any cancer cells encountered on the road. At the same time "suicide switch" - forcing them to self-destruct before spreading to other organs or tumor formation itself is also active.
Cancer-regulating cancer cells (green) attack cancer cells (red).
Researchers use two combined methods to test their theory. The experiment was carried out on mice with primary brain tumors, recurrent brain tumors and metastasized to the brain.
As expected, both methods of using killer cells not only shrink the tumor size significantly but also increase the viability of the mouse.
The results are published in the July 11, 2018 issue of Science Translational Medicine, which is not the first attempt to make cancer cells destroy each other.
Dr. Khalid Shah from Harvard Medical School and Stem Cell Research Institute, the lead researcher said in a speech: "This is just the surface. Potential cell-based treatments. It is huge in bringing the therapeutic factor to the tumor, which will give us more options when the conventional method fails. "
"With this technology, we want to prove that reconstructing cancer cells and using them to treat cancer is possible. We think this will have a lot of impact and can be applied on all. types of cancer cells ".
The new method is expected to work on all types of cancer.
Currently it is not possible to ensure that this method will work in people similar to the mouse, but this is still a good sign.
The work is at an early stage and there will be more trials in the future, if successful, this technology promises to bring a quick, accurate and effective method of cancer treatment.
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