Biological glues help to regenerate bone naturally

In order to treat cases of children with congenital skeletal deformities, those who suffer from bone loss due to injury or support dental implants, scientists at the University of Iowa (USA) have created high types. The paste has the ability to regenerate the missing bone without worrying about grafting.

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Photo: Gizmag

The new bio- glaze includes a collagen frame and is designed to fit into areas where bone regeneration is needed. They work by supplying directly to bone cells nanoparticles containing synthetic DNA derived from platelets called PDGF – B. It is the growth factor PDGF – B that promotes cells to make proteins that help bone tissue grow.

The study author, Professor Aliasger Salem, said that when the host's bone cells come into contact with the collagen frame containing synthetic DNA, they encode PDGF – B and begin to regenerate bone, synonymous with bone healing. begin. In the experiments, the group of biochemist implants, 5x2mm in size, on the skull of a living laboratory mouse. The results after four weeks showed that the patch contained DNA molecules that helped the bones and soft tissue in the area suffered 44 times more bone growth than the non-PDGF-B type and 14 times the non-controlled area. treatment.

According to Medical News Today, previous studies have shown that experts can use protein to support bone regeneration from outside the body to help bone tissue grow. However, the limitation of this method is that doctors must continuously inject protein for patients during the treatment process. The new method overcomes this problem by allowing PDGF-B to continuously interact with bone cells and create its own protein source. Another benefit of high paste containing synthetic DNA is that it does not cause an immune response, a process that causes the body to dispose of the implants.