Caffeine and type 2 diabetes

' It seems that the amount of SHBG protein in the blood reflects genetic susceptibility to developing type 2 diabetes ,' said Dr. Simin Liu. ' But now, we know that the amount of SHBG protein present in the blood may be affected by factors such as diet .'

Dr. Simin Liu.

Currently, researchers at UCLA have discovered that caffeine in coffee works to stimulate the liver to increase the production and release of large amounts of SHBG (Sex hormone binding globulin) into the blood and protein. SHBG is also called sex hormone-binding globulin , which regulates the biological activity of sex hormones of the body, including the hormone testosterone and hormone estrogen . Drinking four cups of coffee daily will increase the amount of SHBG protein in the blood , contributing to protecting the user's body against the development of type 2 diabetes .

The researchers identified 359 new cases of diabetes by age and race, compared to 359 healthy people, among nearly 40,000 women enrolled in Women's Health Study , a trial. Initial large-scale trials are designed to assess the benefits and risks of using aspirin and low-dose vitamin E in the prevention of cardiovascular disease and cancer.

Scientists found that women who drank four cups of coffee with caffeine daily had a significantly higher increase in the amount of SHBG protein in their blood, as well as achieving a 56% less likely to develop. Diabetes is more than women who don't drink coffee. People who drink coffee without or filtered off caffeine will not benefit from protection from type 2 diabetes.

The findings were published in the journal Diabetes , January 12, 2011, according to Atsushi Goto , the first author of the paper and graduate student at UCLA and David Geffen University, professor of medicine at UCLA University, found that women who drank at least four cups of coffee a day reduced their risk of developing diabetes by more than half compared with those who did not drink coffee.

When the researchers tried to deliberately reduce the amount of SHBG protein in the blood, the effect of protecting coffee drinkers from type 2 diabetes disappeared.

The American Diabetes Association estimates that nearly 24 million children and adults in the United States have diabetes, accounting for nearly 8% of the population. Type 2 diabetes is the most common and currently accounts for 90% to 95% of these cases.

The study confirmed the existence of an opposite trend between coffee consumption and the risk of type 2 diabetes, according to Dr. Simin Liu. This means that the more people drink coffee, the lower the risk of diabetes.

' But how exactly the mechanism works is not observed ,' says Simin Liu, ' although we now know that the amount of SHBG protein present in the blood is important as a marker. Early signs to assess the level of risk and prevent the onset of diabetes. '

According to previous research by Liu and colleagues published in the New England Journal of Medicine , they identified two mutations in the SHBG protein encoding, a mutation that works to increase the The risk of developing type 2 diabetes, while the remaining mutations work to reduce the risk of developing diabetes, and this depends on the amount of SHBG proteins present in the blood.