Discovered 4 genes that help people live longer than 100 years old

ABO, CDKN2B, APOE and SH2B3 are 4 genes that, if owned, you can reach life expectancy beyond 100 years old. That is the conclusion of scientists according to the latest research on the correlation between certain genetic factors for human life expectancy.

Using a completely new approach, the team of scientists led by Stuart Kim at Stanford University's Genetic Research and Development Institute of Biotechnology has found a link between the four regulatory genes. Very long life. Those four genes are:

1. ABO: Specifies blood type.
2. CDKN2B: Help adjust the life cycle of cellular networks.
3. SH2B3: Gene has been shown to help prolong the life cycle of fruit flies.
4. APOE: one of the HLA genes, which is involved in the process of the immune system recognizing cells in the body.

Professor Kim said: " There are many genetic components that contribute to life a hundred years old and we want to determine what it is. We are beginning to unravel the mysteries behind the mobile factors. transmit it ". Previous studies have tried to identify mutant genes that appear in very old people compared to young people, but they still don't have many useful discoveries. The reason is that these studies all look through millions of variants in the human genome, but they may have missed some important genes involved.

There are many genetic components that contribute to the life of a hundred years old.

In this new study, Professor Kim wants to narrow the scope of the search to genes that are involved in prolonging life by focusing on people at high risk of aging diseases such as cardiovascular disease, Alzheimer's. . According to researchers, it is often thought that these diseases will increase the risk of premature death in infected people and therefore the occurrence of these mutations will reduce the chances of life expectancy of people. there.

First, the team looked for genes involved in longevity in the group of 800 people over the age of 100 and 5400 people aged 90 and older. They found eight genes involved in long and last lifespan, identifying four genes for follow-up analysis among 1000 people. Specifically, the occurrence of mutations of four genes , ABO, CDKN2B, APOE and SH2B3 in people over 100 years old, is higher than those with normal life expectancy (adults in the US have an average life expectancy of about 79 years according to the US Centers for Disease Control and Prevention data.

For example, research has found that mutations in genes related to blood type O appear to be common in people over 100 years of age in the study, and that means that people over 100 will have group ownership. blood O is higher than normal. Previous studies have also shown that people with type O blood are less likely to develop cardiovascular disease and cancer, have lower cholesterol levels than people with other blood types.

Another form of genetic variation in the CDKN2B gene, which regulates cell division or division, also plays an important role in this study. Because cytolysis will contribute to aging, and if the gene is mutated to reduce aging cells, continue to divide, the overall aging of the person will be slower, from which people will live longer.

However, Professor Kim thinks there are still many more genes related to the results of life expectancy: "I hope that our report will inspire others to continue to look for people to pull. Long life in the future ".