Find out the top two causes of aging

By using genetic information on genee from many biological banks, the Japanese team can predict in advance the factors that affect human life expectancy.

In a study published in Nature Medicine, a team led by Professor Yukinori Okada at Osaka University in Japan showed genetic traits that influence aging.

High blood pressure and obesity are the two leading causes of rapid aging in humans. (Photo: Getty).

Although single genes are commonly known to establish biological traits such as eye color and blood type, most complex, inherited diseases are not the result of a single gene variant that produces comes from a combination of multiple genetic variants.

Therefore, instead of assessing the impact of a single gene, Professor Yukinori Okada's team calculated the multi-gene risk score of aging genetic traits on the genome taken from the data analysis. by Biobank.

In genetics, the multi-genee risk score (also known as the genetic risk score) , is widely used on plant and mobile genetics to determine their genetic predisposition to complex genetic traits. Such as height, circadian rhythms, enzyme kinetics or many diseases such as diabetes, Parkinson's.

Therefore, by calculating the multi-gene risk score, scientists can use genetic information to predict factors that affect unhealthy, reducing life expectancy.

'Genetic codes contain a lot of information, but most of them don't make sense to us. The goal our study sets out is to use that genetic information to uncover the causes of adverse health effects. If successful, we will identify the exact pathogens on the human body , '' Okada said.

To do this, the researchers analyzed and researched genetic and clinical information (information obtained from patients' treatment) of nearly 700,000 volunteers from Biobank biological banks in the UK, Finland and Japan. From the research data, they calculated the multi-gene risk score.

'Biobank biological banks are an incredible resource. By combining data from large biobankers in the UK, Finland and Japan, we not only have access to large amounts of data, but we can also discover many genetic traits in the genes of volunteers. These are both essential factors for making clinically meaningful conclusions , '' said Dr. Saori Sakaue, who led the research.

genee plays a leading role in genetics. (Photo: Asian Scientist).

According to Asian Scientist, Okada's team has found that high blood pressure and obesity are the two factors most at risk of reducing the life expectancy of people today . Interestingly, while high blood pressure reduced life expectancy among all investigators, obesity reduced the life expectancy of Europeans even more.

This suggests that in some ways, Japanese people are protected from the adverse effects on their longevity.

'These are clear results showing that genetics can be used to predict health status. Our research has come up with a solution that uses genetic information to look for risk factors that could adversely affect health.

The goal of this is to help people detect germs early and quickly change their lifestyles and prepare for treatment. Ultimately, we believe this approach will improve the health of the entire population in the future, ' Okada said.