Finding genes that are involved in height development in humans

Geneticists are learning how the gene controls the development of human height. The short answer is that there are at least 180 different common gene variants involved. The detailed answer is that there are more than 600 gene variants that control human height.

A quick look at the genetic blueprint of more than 100,000 people concluded that at least 180 different gene variants are involved in determining height in humans , researchers have discovered. This is in Nature (September 29, 2010). It was impressive, but the fact that each of the genes involved would have only a negligible effect and the researchers calculated that only about 10% of the genes would contribute to the so the height development is outstanding in people.

" It is much more complicated than our original estimate, which could have thousands of gene variants that cause small effects, " said Michael Weedon, a geneticist at Peninsula College of Medicine & Dentistry in Exeter, England. . Weedon is one of the 293 co-authors of the new study, re-analyzing data obtained from more than 50 studies of the human genome in search of genes that affect height growth.

Larger studies can help detect many gene variants that are involved in height development in humans. Assuming that all gene variants have modest effects in this study, the researchers estimate that there are between 483 and 1,040 different gene variants that involve a height increase of one millimeter. Scientists are still discussing the direction of further research on the effect of genes on height development in humans.

Nutrition and environmental factors also contribute to the development of height , according to Geneticist Aravinda Chakravarti, working at the Johns Hopkins University School of Medicine in Baltimore, Maryland, USA. It is easy to recognize that children in migrant families often have higher height than their parents because they enjoy better nutrition right from birth. The results of this study help scientists find the most optimal diet to help people achieve the ideal height, while providing new treatments for children of modest stature instead of using data. Treatment with growth hormone.

Through studies of the development of height in humans, scientists have a better understanding of the number of genes that directly affect human disease. According to Jeffrey Barrett, statistical geneticist, working at the Wellcome Trust Sanger Institute near Cambridge, England "" This gives us a better understanding of the architecture of other features in the human body . "

Although these studies have helped scientists locate genomes that contain important genes, it is unclear whether height development or other traits in affected people. by many genetic variants with small effects or because of a few rare gene variants that have significant effects, says David Goldstein, a geneticist at Duke University in Durham, North Carolina, USA.

In the future, when scientists begin to arrange a complete genetic map of people in the right order to find genetically engineered genetic variants, the results of human genome studies will ever be Data sources are very meaningful.

These genome-wide studies will help scientists discover biological processes involved in causing or protecting against disease, adds geneticist Aravinda Chakravarti.

-------------------------------------------------- -------------------------------------------------- -

Ho Duy Binh
Address : Library Information Center - Tien Giang University - No. 119, Bac Hamlet, Ward 5, TP. My Tho, Tien Giang province.
Email : hoduybinhdhtg@cooltoad.com