Inflammation contributes to colon cancer

Researchers led by Dr. Washington Irinani Dr. Brian Iritani found that Smad3-resistant molecules are very sensitive to bacterial and cancer inflammation.

Bacteria play a small role in shaping some types of cancer by stimulating chronic inflammation. The lack of a molecule that blocks inflammation, Smad3, may increase the risk of colon cancer.

Colon cancer. ( Photo: gastrocentralva.com )

To test whether Smad3 has a role in developing colon cancer, Maggio-Price and colleagues looked at mice lacking Smad3 and adaptive resistance responses. They found that these mice were very sensitive to bacterial inflammation and cancer due to the lack of T-cell function and the proliferation of inflamed cells. Through the increase of cancer-causing proteins and self-destructive proteins, epithelial cells in the colon tissue improve growth and survival.

Dr. Iritani explains: 'The inflammatory response to microorganisms is a key factor in the results of the important tumor blockers' function for Smad3 in T cells, intestinal epithelial cells, pine. often limits the development of colon cancer when responding to bacterial inflammation '.

Refer:

1. Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamons A, Drivdahl R, Zeng W, Lai LH, Huycke M, Phelps S, Brabb T1, Iritani BM.Lỗi trùngAm J Pathol, 2009, 174: 317-329