Reconstructing bone from bone marrow cells and carbon materials

Scientific experts from the Ulsan National Institute of Science and Technology (UNIST) have successfully studied bone regeneration techniques from stem cells in bone marrow and carbonated photocatalyst materials. This study will be a new breakthrough in treating bone-related injuries, such as fractures or periodontal disease.

In collaboration with Youngkyo Seo professors, Professor Kwang S. Kim, Professor Pann-Ghill Suh and Dr. Jitendra N. Tiwari and seven other scientists from the UNIST Institute, new bone regeneration techniques The initial results were very positive.

According to the study, scientists used carbon nitride (C ₃ H ₄ ) to absorb red light to regenerate as well as enhance bone system function by transcriptional regulation of the Runx2 gene. active. The team hopes that the results of this study can create a new breakthrough for bone regeneration techniques.

From left is Professor Youngkyo Seo and Dr. Jitendra N. Tiwari in the laboratory at UNIST.(Source: UNIST).

The use of bone marrow mesenchymal stem cells (hBMSCs) has been successfully tested in the treatment of pathology related to the bone system. Recently, many research efforts by experts have promoted biological treatments to enhance the function of stem cells by using carbon nanotubes, graphenes, and nano oxides.

During the study, scientists discovered carbon nitride materials capable of absorbing red light and emitting fluorescence, which accelerates the regeneration of bone tissue. Professor Kim's team synthesized derivatives of nitrogen carbon from melamine compounds. They then analyzed the light absorption properties of carbon nitride.

As a result, carbon nitride is capable of emitting fluorescence at a wavelength of 635nm when exposed to red light in liquid state. At this point, the electrons will produce calcium in the stem cells.

The left image is the chemical bond and the physical structure of C₃N₄4.Right picture After 4 weeks C₃N₄4 compound is more synthesized.In liquid state, red light is transmitted at 450nm wavelength and emitted at a wavelength of 635nm.

"This study will open the possibility of developing a new drug that is resistant to bone injuries, such as fractures and osteoporosis , " said Professor Young-Kyo Seo. "This will be a new step in creating bone from stem cells and 3D printing technology."

He added: "This is an important milestone in analyzing the biological functions needed for the development of biological materials, including auxiliary substances for hard tissues such as damaged bones and teeth. ".