The liver can 'contend' the brain's protein

Researchers found that, in the human body, the liver can "eat" of the brain. This may be the reason why people with abdominal obesity face the risk of developing dementia three times higher in life than their peers who possess a firmer second round.

According to a new study by Rush University Medical Center (Chicago, USA), in the animal body, both the liver and the hippocampus memory brain region are "hungry" for a protein called PPARalpha . The liver uses PPARalpha to burn fat to accumulate into belly fat, while the hippocampus brain region uses this protein to handle memory and learning.

Experts found that in people with abdominal obesity or the amount of fat accumulated around the large abdomen, the liver needed to work overtime to metabolize fat and use up all PPARalpha. This process takes place as follows: first, the liver "corrodes" protein stores in place, then sweeps the supply where it remains throughout the body, including the brain.

According to the researchers, if a deficiency of PPARalpha protein, the brain's memory process will have problems.(Artwork: Shutterstock)

The process basically devoured both PPARalpha's "food" of the brain, "starved" of the hippocampus and thus hindered memory and learning. This may be the reason for the relationship between belly fat and dementia.

According to Cell Reports magazine, Rush University team raised mice that lacked PPARalpha protein. Some rats possessed normal levels of PPARalpha in their liver but suffered a decline in this protein in the brain, so they had poor memory and learning ability. The rest of the mice had normal PPARalpha levels in the brain but decreased in the liver, showing normal memory.

When the researchers injected PPARalpha into the hippocampus brain region of mice with this protein deficiency, their ability to learn and remember has improved.

Neuroscientist Professor Kalipada Pahan, who led the study, said his findings and his colleagues alluded to PPARalpha opening up the prospect of a new treatment for dementia and Alzheimer's disease. problems related to cognitive ability and memory. Mr. Pahan also emphasized that more research is needed to see how we can maintain normal PPARalpha levels in the brain to combat dementia.