Use stem cells of human blood to kill HIV

A study has shown that it is possible to use human stem cells to produce cells capable of killing HIV-infected cells.

The result may lead to the production of this type of genetic vaccine that is not only good news in the fight against HIV but can also be used to combat a wide range of chronic viral illnesses.

In the study, researchers at the University of California AIDS Institute and colleagues took 'exterminated' T cells with anti-inflammatory functions, called CD8 T-cells, from an infected person. HIV.

They then identified molecules called T-cell receptors - a type of molecule that guides T cells to identify and kill HIV-infected cells.

Although this type of cell is capable of killing HIV-infected cells, in numbers they are not enough to eliminate HIV in the body.

Blood cells.Illustration.

So the researchers cloned the T-cell receptor and genetically modified the stem cells of blood, followed by placing stem cells into human thymus tissue, cultured in mice, to Study reaction in a living organism.

The inserted stem cells produced large amounts of multifunctional adult CD8 cells capable of destroying cells containing HIV proteins.

The researchers also found that the above anti-HIV T-cell receptor needs to be reconciled with an organ similar to an organ that must be suitable for transplant patients.

However, the results of the study suggest that this method could become an effective weapon in the fight against AIDS, and researchers also hope to expand the scope of virus killing through this approach.

Leading members of the study, Associate Professor of Hematology and Cancer Scott G. Kitchen of David Geffen School of Medicine at the University of California, AIDS Institute member, evaluated: "These studies lay the foundation for the delivery. Develop treatments that involve restoring a compromised immune response caused by a variety of viruses, or even different types of tumors . '