Causes of DNA fracture in cancer cells

DNA destruction is a typical sign of cancer cells. Although it was previously thought that normal cell damage was caused by negative effects on DNA replication when cancer cells invaded, the molecular basis of this problem has not been clarified. .

So far, for the first time, researchers at Hebrew University in Jerusalem have shown that in the early stages of cancer development, cells do not have enough ' structural units ' - nucleotides provide for the doubling process. normalization of DNA . This can be stopped by proactively adding more nucleotides, which reduces the risk of DNA damage and can significantly reduce the ability of cells to develop cancer properties. Therefore, it is hoped that this facility will provide a way to protect against cancer development.

Performed in the Hebrew University laboratory, Professor Batsheva Kerem and colleagues reported that abnormal cell reproduction activities led to many different types of cancer causing a lack of DNA - nucleotide structural units to can guarantee normal DNA replication.

Then using a lab culture for cancer cells, the researchers showed that by providing more nucleotides, it could replicate normal DNA synthesis, which in turn would be ineffective. Harmful effects caused by cancer cells and cancer risk. This conclusion was first made.

The study was published in the journal Cell, researchers at the Hebrew University said, and led to the development of new measures to protect against pre-cancer development, even to create how to reduce the DNA breakdown.