Detecting mechanisms for developing Alzheimer's disease early on

Xinhua cited the latest discovery by a Japanese research group that early on, Alzheimer's disease was caused by mutated helicase function that led to unresolved DNA sequences in cells.

The results of this study have been published in the latest issue of 'structure' of the US.

Alzheimer's disease is an early disease in people older than 10 years, the body's aging rate is about twice that of a normal person, the average life expectancy of a patient is not 50 years old. Currently, there are thousands of people worldwide suffering from this disease.

The group of scientists from Nara High-tech Research Institute (Japan) took advantage of synchronous radiation equipment to conduct detailed analysis of the structure and function of helicase.

As a result, stable helicase can produce small knife-shaped proteins and is very suitable for DNA resolution and regulation of aging telomere.

Meanwhile, helicases in people with Alzheimer's disease were unable to produce this protein with a small knife-shaped structure, thus resulting in shorter telomere speeds than normal people, eventually make the patient old before age, and the life expectancy is shortened.

Kitano, the research leader, expressed his hope that the results of the study will not only benefit early treatment of Alzheimer's disease, but will also be beneficial for slowing down aging and preventing cancer.