Detection of B2M protein accumulates in the blood associated with memory impairment

According to a study published in July 6 in the Journal of Natural Medicine (Nature Medicine), a protein molecule called B2M accumulates in the blood over time and age, which may be related to intellectual impairment. in humans.

B2M protein accumulates in the blood causing memory impairment

B2M , a protein related to the immune system, mainly accumulates densely in the blood and cerebrospinal fluid of older people.

(Source: AFP)

Through research on white mice at the lab , scientists at the University of California at San Francisco in the US, found that blocking B2M molecular numbers increases the ability to perceive and remember events. .

Scientist Saul Villeda, one of the authors of the study, said the findings help identify two ways to significantly reverse age-related memory decline .

One is the addition of rejuvenating molecules in the blood and the other is to prevent the proliferation of aging molecules like B2M.

Last year, Villeda, who participated in another study, found that injecting immature mice 'blood would increase the perception and memory of older mice.

Older mice, after injecting blood from healthy mice, become nimble and have a better memory. However, at that time, the team did not explain the cause of this phenomenon.

Through a second study, the team this time suggested that B2M may help explain why the blood of young mice may increase memory capacity. That's because injecting B2M reduces the cognitive, memory and neuronal development of lab rats, and when the injection of this protein stops, the results are contradictory.

According to the plan, the team will continue to take the next step: developing a new molecule or preventing the growth of B2M protein or helping to remove this protein from the blood of the elderly.

Age is related to the rapid decline in memory function and to the slow recovery of neurons that receive messages in the brain. This is also the leading risk of causing dementia like Alzheimer's.

Therefore, with the above findings, American scientists hope to find a treatment soon to help restore memory effectively.