Evergreen plant and breast cancer

An effective drug extracted from evergreen tree (evergreen tree) can save patients who are in danger of dying from breast cancer.

According to the US National Cancer Institute, about 40,000 people with breast cancer are reported this year in the United States.

Scientists working at UC Santa Barbara University have partnered with scientists working in The pharmaceutical industry, together discovering the mechanism of killing the cancer cells of this drug. The team successfully separated the reactions of in vitro drugs and cancer cells.

The findings were published in the Molecular Cancer Therapeutics issue in October 2010 by researchers at UC Santa Barbara University. The articles describe specific lab work written by Mary Ann Jordan and Leslie Wilson, two professors from UC Santa Barbara's Department of Cellular, Molecular and Developmental Biology.

" The drug called maytasine has an anti-cancer effect when it is combined with antibodies that kill the tumor, which has brought promising results in clinical trial treatment on Ung patients. Metastatic breast cancer , 'according to Mary Ann Jordan.' Although Maytansine has not been approved by the US Food and Drug Administration (FDA), Maytansine has yielded promising results in Clinical trial treatment in patients Metastatic breast cancer, and drugs are also being tested on other cancers such as multiple myeloma, B-cell lymphoma (lymphoma) '.

Early tests showed that Maytansine reduced the size of tumors by one-third in patients with breast cancer , an unimaginable result, according to the researchers, Maytansine attacks the catheters. microtubes (microtubes). Microtubules help fight cells and help cancer cells reproduce.

" We learn how Maytansine drugs get into cancer cells ," said Mary Ann Jordan. " We found that it metabolizes cancer cells, suppresses the dynamics of microtubes, preventing cancer cells from dividing, preventing cancer cells. metastasize, and make them die . ".

In the past, Maytansine was considered too dangerous to use, because it destroyed benign cells. However, the team thinks that it is possible to inhibit the toxicity of Maytansine by adding an antibody for the purpose of causing the drug to kill only cancer cells.

A new drug called trastuzumab-DM1 binds to antibodies that attack breast cancer cells. DM1 is also a synthetic derivative of maytansine, a material found in an evergreen tree of the genus Maytenus, which grows naturally on many continents.

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Ho Duy Binh
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