Look for compounds that help prevent noise-induced hearing loss

(Listen now) - Now listen to this: Scientists discover that compounds help prevent noise-induced hearing loss.

Your mother was right when she warned you that loud music could be dangerous for your ears, but now scientists have discovered exactly what is dangerous and how to cause it. Dangerous for your ears. In a research report published in The FASEB Journal, scientists accurately described how noise harms the inner ear, and provides a deeper look at a compound that has can help prevent noise-related effects.

'Noise-induced hearing loss, along with accompanying tinnitus and sound sensitivity are a major manifestation of communication and social isolation issues' , Xiaorui Shi, MD, Ph.D . The author of the study came from the Department of Otolaryngology / Head and Neck Surgery at the Center for Hearing at the University of Science and Health in Portland, Oregon. 'The purpose of our study is to fully understand the molecular mechanisms to alleviate the effects of exposure to loud sounds.'

To get this discovery, Shi and colleagues used three groups of 6 - 8 old mice, including a control group, a group exposed to noise in a wide band at 120 dB in intensity. within 3 hours a day and lasts for two days, and the third group is given a dose of epithelial pigment factor derived from PEDF.

Epithelial factor derived from (PEDF) also known as serpin F1 (SERPINF1) , is a multi-functional protein, has anti-angiogenic, anti-tumor, and neurological function. PEDF is a protein found in vertebrate animals and is currently being studied for the treatment of diseases such as heart disease and cancer.

Cells that release PEDF in controlled animals have shown a characteristic branching pattern, with cells arranged in a self-avoidance model that creates a lumped area into the wall. circuit. The morphology of similar cells in mice exposed to loud noise, however, showed marked differences - noise exposure causing changes in the melanocytes in the inner ear .

"Listening down gradually over time will reduce the quality of human life , " said Gerald Weissmann, chief editor of the FASB headquarters. It is easy to say that we should stay away from loud noise, but in practice. This is not always possible.

Frontline soldiers or first responders do not have time to worry about the long-term effects of loud noise when they are in front of their lives. However, if a drug can be researched and developed to minimize the negative effects of loud noise, this will benefit everyone.